A genome screen for multiple sclerosis in Sardinian multiplex families

被引:69
作者
Coraddu, F
Sawcer, S
D'Alfonso, S
Lai, M
Hensiek, A
Solla, E
Broadley, S
Mancosu, C
Pugliatti, M
Marrosu, MG
Compston, A
机构
[1] Univ Cagliari, Ctr Diagnosi & Cura Sclerosi Multipla, Osped Binaghi ASL8, I-09100 Cagliari, Italy
[2] Univ Cambridge, Addenbrookes Hosp, Neurol Unit, Cambridge CB2 2QQ, England
[3] Univ Piemonte Orientale A Avogadro, Dept Med Sci, Novara, Italy
[4] Univ Sassari, Neurol Clin, I-07100 Sassari, Italy
基金
英国惠康基金;
关键词
multiple sclerosis; linkage; genome screens; Sardinians;
D O I
10.1038/sj.ejhg.5200680
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The prevalence of multiple sclerosis in Sardinia is significantly higher than in neighbouring Mediterranean countries, suggesting that the isolated growth of the population has concentrated genetic factors which increase susceptibility to the disease. The distinct HLA association of multiple sclerosis in Sardinia supports this interpretation. We have performed a whole genome screen for linkage in 49 Sardinian multiplex families using 327 markers. Non parametric linkage analysis of these data reveal suggestive linkage in the region of Chr 1q31, Chr 10q23 and Chr 11p15.
引用
收藏
页码:621 / 626
页数:6
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