Antiviral activity of caspase inhibitors: effect on picornaviral 2A proteinase

被引：39

作者：

Deszcz, L ^{[1
]}

Selpelt, J ^{[1
]}

Vassilieva, E ^{[1
]}

Roetzer, A ^{[1
]}

Kuechler, E ^{[1
]}

机构：

[1] Univ Vienna, Div Biochem, Dept Med Biochem, Vienna Bioctr,Univ Dept,Max F Perutz Labs, A-1030 Vienna, Austria

来源：

FEBS LETTERS | 2004年 / 560卷 / 1-3期

基金：

奥地利科学基金会;

关键词：

rhinovirus; picornavirus; 2A proteinase; eIF4GI cleavage; caspase inhibitor; apoptosis;

D O I：

10.1016/S0014-5793(04)00069-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peptide-based fluoromethyl ketones have been considered for many years to be highly specific caspase inhibitors distinctly blocking the progress of apoptosis in a variety of systems. Here we demonstrate that these compounds can significantly reduce rhinovirus multiplication in cell culture. In their methylated forms they block eIF4GI cleavage in vivo and in vitro and inhibit the activity of picornaviral 2A proteinases (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：51 / 55

页数：5

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