Disseminated histoplasmosis in primary Sjogren syndrome: A case report

被引：1

作者：

Li, Jia-Ai ^{[1
]}

Cheng, Ying-Ying ^{[1
]}

Cui, Zhi-Tao ^{[2
]}

Jiang, Wei ^{[1
]}

Zhang, Wu-Qiong ^{[1
]}

Du, Zhong-Hua ^{[3
]}

Gao, Bin ^{[1
]}

Xie, Yin-Yin ^{[1
]}

Meng, Hong-Mei ^{[1
]}

机构：

[1] First Hosp Jilin Univ, Dept Neurolop, 71 Xinmin St, Changchun 130021, Jilin, Peoples R China

[2] First Hosp Jilin Univ, Dept Geriatr, Changchun 130021, Jilin, Peoples R China

[3] First Hosp Jilin Univ, Dept Hematol, Changchun 130021, Jilin, Peoples R China

来源：

WORLD JOURNAL OF CLINICAL CASES | 2020年 / 8卷 / 07期

基金：

国家重点研发计划;

关键词：

Sjogren syndrome; Infection; Disseminated histoplasmosis; Pancytopenia; Central nervous system involvement; Hematologic manifestations; CLINICAL-FEATURES; INFECTION; MANAGEMENT; DIAGNOSIS; DISEASE;

D O I：

10.12998/wjcc.v8.i7.1319

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND Sjogren syndrome (SS) is a chronic and systemic autoimmune disease characterized by lymphocytic infiltration of the exocrine glands. And histoplasmosis is an invasive mycosis caused by the saprophytic dimorphic fungus H. capsulatum. In patients with primary SS (PSS), disseminated histoplasmosis (DH) is extremely rare. CASE SUMMARY We report a 37-year-old female patient admitted to our hospital with exacerbating fatigue, somnolence, and pancytopenia as the main symptoms. She was eventually diagnosed with DH based on pancytopenia, splenomegaly, and findings of bone marrow smears. The atypical clinical symptoms made the diagnosis process more tortuous. Unfortunately, she died of respiratory failure on the day the diagnosis was confirmed. CONCLUSION We present a rare and interesting case of DH in a PSS patient. This case updates the geographic distribution of histoplasmosis in China, and expands the clinical manifestations of DH in PSS, highlighting the significance of constantly improving the understanding of PSS with DH.

引用

页码：1319 / 1325

页数：7

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