High-Efficiency Upconversion Luminescent Sensing and Bioimaging of Hg(II) by Chromophoric Ruthenium Complex-Assembled Nanophosphors

被引：236

作者：

Liu, Qian ^{[1
]}

Peng, Juanjuan ^{[1
]}

Sun, Lining ^{[2
]}

Li, Fuyou ^{[1
]}

机构：

[1] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China

[2] Shanghai Univ, Res Ctr Nano Sci & Technol, Shanghai 200444, Peoples R China

来源：

ACS NANO | 2011年 / 5卷 / 10期

基金：

美国国家科学基金会;

关键词：

bioimaging; ratiometric; upconversion luminescence; Hg2+; NEAR-INFRARED NIR; UPCONVERTING NANOPARTICLES; HG2+ IONS; NANOCRYSTALS; FLUORESCENT; CHEMODOSIMETER; STRATEGY; SENSOR; PHASE; CELLS;

D O I：

10.1021/nn202620u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A chromophoric ruthenium complex-assembled nanophosphor (N719-UCNPs) was achieved as a highly selective water-soluble probe for upconversion luminescence sensing and bioimaging of intracellular mercury Ions. The prepared nanophosphors were characterized by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), energy-dispersive X-ray analysis (EDXA), Fourier transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS). Further application of N719-UCNPs in sensing Hg2+ was confirmed by optical titration experiment and upconversion luminescence live cell Imaging. Using the ratiometric upconversion luminescence as a detection signal, the detection limit of Hg2+ for this nanoprobe in water was down to 1.95 ppb, lower than the maximum level (2 ppb) of He2+ in drinking water set by the United States EPA. Importantly, the nanoprobe N719-UCNPs has been shown to be capable of monitoring changes in the distribution of Hg2+ in living cells by upconversion luminescence bioimaging.

引用

页码：8040 / 8048

页数：9

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