Acrocalysterols A and B, two new steroids from endophytic fungus Acrocalymma sp

被引：6

作者：

Yang, Ting ^{[1
]}

Liu, Jie ^{[1
]}

Lin, Li-Bin ^{[1
]}

Hu, Jia-Yao ^{[1
]}

Wu, Guang-Wei ^{[2
]}

Fan, Pei-Hong ^{[3
]}

Duan, Dong-Zhu ^{[1
]}

Xiao, Jian ^{[1
]}

Wang, Xiao-Ling ^{[1
]}

机构：

[1] Baoji Univ Arts & Sci, Coll Chem & Chem Engn, Shaanxi Key Lab Phytochem, Baoji 721013, Peoples R China

[2] Nanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Peoples R China

[3] Shandong Univ, Sch Pharmaceut Sci, Dept Nat Prod Chem, Key Lab Chem Biol,Minist Educ, Jinan 250012, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2022年 / 48卷

基金：

中国国家自然科学基金;

关键词：

Sinomenium acutum; Endophytic fungus; Acrocalymma sp; Steroid; Cytotoxicity; SECONDARY METABOLITES; SINOMENIUM-ACUTUM; DERIVATIVES; CONSTITUENTS;

D O I：

10.1016/j.phytol.2022.02.003

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new steroids, named acrocalysterols A (1) and B (2), together with five known compounds were isolated and characterized from an endophytic fungus Acrocalymma sp., isolated from the tender stems of Sinomenium acutum. The structures of the isolated metabolites were identified based on UV, IR NMR (1D and 2D), HR-ESI-TOF-MS, single-crystal X-ray diffraction experiment using Cu K alpha radiation and CD spectra associated with TD-DFT calculation. The bioassay showed that compound 2 displayed potent cytotoxicity against three cancer cell lines HeLa, HCC-1806, and RKO with IC50 values ranging from 18.37 to 19.64 mu M.

引用

页码：77 / 80

页数：4

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