The impact of age and nodal status on variations in oncotype DX testing and adjuvant treatment

被引：14

作者：

Iles, Kathleen ^{[1
]}

Roberson, Mya L. ^{[2
,3
]}

Spanheimer, Philip ^{[4
]}

Gallagher, Kristalyn ^{[4
]}

Ollila, David W. ^{[4
]}

Strassle, Paula D. ^{[5
]}

Downs-Canner, Stephanie ^{[4
]}

机构：

[1] Univ N Carolina, Dept Surg, Chapel Hill, NC 27515 USA

[2] Vanderbilt Univ, Sch Med, Dept Hlth Policy, Nashville, TN 37212 USA

[3] Vanderbilt Ingram Canc Ctr, Nashville, TN USA

[4] Univ N Carolina, Dept Surg Oncol, Chapel Hill, NC 27515 USA

[5] Natl Inst Minor Hlth & Hlth Dispar NIMHD, Div Intramural Res, NIH, Bethesda, MD USA

来源：

NPJ BREAST CANCER | 2022年 / 8卷 / 01期

基金：

美国国家卫生研究院;

关键词：

21-GENE RECURRENCE SCORE; BREAST-CANCER; FOLLOW-UP; CHEMOTHERAPY; WOMEN; OLDER; ASSAY; IRRADIATION; CONCORDANCE; DISSECTION;

D O I：

10.1038/s41523-022-00394-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Oncotype DX (ODX) recurrence score (RS) is a validated tool to guide the use of adjuvant chemotherapy (AC) in hormone receptor +/HER2- breast cancer. In this analysis, we examine (1) characteristics associated with ODX testing and (2) the association between ODX RS and receipt of AC across age and nodal status. Women with HR+/HER2-, early-stage (T1-2, N0-1) breast cancers from 2010-2017 in the National Cancer Database were included. 530,125 met inclusion and 255,971 received ODX testing. Older women were less likely to receive testing; however, nodal positivity increased use of testing. High ODX RS was associated with increased mortality, though the association was not consistent across age and was most strongly associated with mortality among younger, node-negative women. Older women with high ODX RS, regardless of nodal status, were less likely to receive AC. Clinicians may be employing ODX RS to support treatment decisions against the receipt of AC.

引用

页数：8

共 42 条

[1] Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial [J].

Albain, Kathy S. ;

Barlow, William E. ;

Shak, Steven ;

Hortobagyi, Gabriel N. ;

Livingston, Robert B. ;

Yeh, I-Tien ;

Ravdin, Peter ;

Bugarini, Roberto ;

Boehner, Frederick L. ;

Davidson, Nancy E. ;

Sledge, George W. ;

Winer, Eric P. ;

Hudis, Clifford ;

Ingle, James N. ;

Perez, Edith A. ;

Pritchard, Kathleen I. ;

Shepherd, Lois ;

Gralow, Julie R. ;

Yoshizawa, Carl ;

Allred, D. Craig ;

Osborne, C. Kent ;

Hayes, Daniel F. .

LANCET ONCOLOGY, 2010, 11 (01) :55-65

[2] Bridging the Age Gap in breast cancer: Impact of chemotherapy on quality of life in older women with early breast cancer [J].

Battisti, Nicolo Matteo Luca ;

Reed, Malcolm W. R. ;

Herbert, Esther ;

Morgan, Jenna L. ;

Collins, Karen A. ;

Ward, Sue E. ;

Holmes, Geoffrey R. ;

Bradburn, Michael ;

Walters, Stephen J. ;

Burton, Maria ;

Lifford, Kate ;

Edwards, Adrian ;

Robinson, Thompson G. ;

Martin, Charlene ;

Chater, Tim ;

Pemberton, Kirsty J. ;

Shrestha, Anne ;

Brennan, Alan ;

Cheung, Kwok L. ;

Todd, Annaliza ;

Audisio, Riccardo A. ;

Wright, Juliet ;

Simcock, Richard ;

Green, Tracey ;

Revell, Deirdre ;

Gath, Jacqui ;

Horgan, Kieran ;

Holcombe, Chris ;

Winter, Matthew C. ;

Naik, Jay ;

Parmeshwar, Rishi ;

Gosney, Margot A. ;

Hatton, Matthew Q. ;

Thompson, Alastair M. ;

Wyld, Lynda ;

Ring, Alistair .

EUROPEAN JOURNAL OF CANCER, 2021, 144 :269-280

[3] Lymph Node Status in Breast Cancer Does Not Predict Tumor Biology [J].

Bello, Danielle M. ;

Russell, Christy ;

McCullough, Debbie ;

Tierno, Marni ;

Morrow, Monica .

ANNALS OF SURGICAL ONCOLOGY, 2018, 25 (10) :2884-2889

[4] Menopausal status does not predict Oncotype DX recurrence score [J].

Carr, Danielle N. ;

Vera, Nora ;

Sun, Weihong ;

Lee, Marie Catherine ;

Hoover, Susan ;

Fulp, William ;

Acs, Geza ;

Laronga, Christine .

JOURNAL OF SURGICAL RESEARCH, 2015, 198 (01) :27-33

[5] Evaluating Use Characteristics for the Oncotype Dx 21-Gene Recurrence Score and Concordance With Chemotherapy Use in Early-Stage Breast Cancer [J].

Chen, Clara ;

Dhanda, Rahul ;

Tseng, Wan-Yu ;

Forsyth, Michael ;

Patt, Debra A. .

JOURNAL OF ONCOLOGY PRACTICE, 2013, 9 (04) :182-+

[6] Twenty-five-year follow-up of a randomized trial comparing radical mastectomy, total mastectomy, and total mastectomy followed by irradiation [J].

Fisher, B ;

Jeong, JH ;

Anderson, S ;

Bryant, J ;

Fisher, ER ;

Wolmark, N .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (08) :567-575

[7] General recommendations paper on the management of older patients with cancer: the SEOM geriatric oncology task force's position statement [J].

Girones Sarrio, R. ;

Antonio Rebollo, M. ;

Molina Garrido, M. J. ;

Guillen-Ponce, C. ;

Blanco, R. ;

Gonzalez Flores, E. ;

Saldana, J. .

CLINICAL & TRANSLATIONAL ONCOLOGY, 2018, 20 (10) :1246-1251

[8] West German Study Group Phase III PlanB Trial: First Prospective Outcome Data for the 21-Gene Recurrence Score Assay and Concordance of Prognostic Markers by Central and Local Pathology Assessment [J].

Gluz, Oleg ;

Nitz, Ulrike A. ;

Christgen, Matthias ;

Kates, Ronald E. ;

Shak, Steven ;

Clemens, Michael ;

Kraemer, Stefan ;

Aktas, Bahriye ;

Kuemmel, Sherko ;

Reimer, Toralf ;

Kusche, Manfred ;

Heyl, Volker ;

Lorenz-Salehi, Fatemeh ;

Just, Marianne ;

Hofmann, Daniel ;

Degenhardt, Tom ;

Liedtke, Cornelia ;

Svedman, Christer ;

Wuerstlein, Rachel ;

Kreipe, Hans H. ;

Harbeck, Nadia .

JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (20) :2341-U66

[9] Lumpectomy Plus Tamoxifen With or Without Irradiation in Women Age 70 Years or Older With Early Breast Cancer: Long-Term Follow-Up of CALGB 9343 [J].

Hughes, Kevin S. ;

Schnaper, Lauren A. ;

Bellon, Jennifer R. ;

Cirrincione, Constance T. ;

Berry, Donald A. ;

McCormick, Beryl ;

Muss, Hyman B. ;

Smith, Barbara L. ;

Hudis, Clifford A. ;

Winer, Eric P. ;

Wood, William C. .

JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (19) :2382-+

[10] Clinical Impact of 21-Gene Recurrence Score Test Within the Veterans Health Administration: Utilization and Receipt of Guideline-Concordant Care [J].

Hull, Leland E. ;

Lynch, Julie A. ;

Berse, Brygida B. ;

DuVall, Scott L. ;

Chun, Danielle S. ;

Venne, Vicki L. ;

Efimova, Olga V. ;

Icardi, Michael S. ;

Kelley, Michael J. .

CLINICAL BREAST CANCER, 2018, 18 (02) :135-143

← 1 2 3 4 5 →