CARBOXYMETHYL CELLULOSE ESTERS AS STABILIZERS FOR HYDROPHOBIC DRUGS IN AQUEOUS MEDIUM

被引：0
|
作者：
El-Sakhawy, Mohamed [1 ]
Salama, Ahmed [1 ]
Kamel, Samir [1 ]
Tohamy, Hebat-Allah S. [1 ]
机构：
[1] Natl Res Ctr, Cellulose & Paper Dept, 33 El Bohouth Str,PO 12622, Giza, Egypt
来源：
CELLULOSE CHEMISTRY AND TECHNOLOGY | 2018年 / 52卷 / 9-10期
关键词：
bagasse; amphiphilic cellulose; carboxymethyl cellulose acetate butyrate; hydrophobic drug; amorphous solid dispersion; sulfadiazine; AMORPHOUS SOLID DISPERSIONS; ACETATE BUTYRATE; SOLUBLE DRUGS; NANOPARTICLES;
D O I：
暂无
中图分类号：
TB3 [工程材料学]; TS [轻工业、手工业、生活服务业];
学科分类号：
0805 ; 080502 ; 0822 ;
摘要：
In the present study, amphiphilic polymers, carboxymethyl cellulose acetate (CMCA) and carboxymethyl cellulose acetate butyrate (CMCAB), with hydrophobic and hydrophilic moieties, were prepared from cellulose extracted from bagasse. The prepared amphiphilic celluloses were characterized by Fourier transform infrared spectroscopy (FTIR) and transmission electron microscopy (TEM). These esters were investigated as stabilizers of sulfadiazine drug in water dispersion. The results showed that CMCAB had higher drug loading efficiency than CMCA.
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页码：749 / 757
页数：9
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