Brain Water Content: a Misunderstood Measurement?

被引：102

作者：

Keep, Richard F. ^{[1
,2
]}

Hua, Ya ^{[2
]}

Xi, Guohua ^{[2
]}

机构：

[1] Univ Michigan, BSRB, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Neurosurg, Ann Arbor, MI 48109 USA

来源：

TRANSLATIONAL STROKE RESEARCH | 2012年 / 3卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Brain edema; Swelling; Water content; Cerebral hemorrhage; Cerebral ischemia; INTRACEREBRAL HEMORRHAGE; CEREBRAL EDEMA; WHITE-MATTER; ISCHEMIA; INJURY; RAT;

D O I：

10.1007/s12975-012-0152-2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Brain edema is a major contributor to poor outcome following ischemic and hemorrhagic stroke. In animal models, edema has historically been quantified as a change in brain water content expressed as a percentage of wet weight (% water content). As described in this communication, this number can be misleading, as "small" changes in percentage of brain water content actually reflect much bigger changes in brain swelling. Using either water content, expressed as grams per gram of dry weight, or a measure of brain swelling better reflect the impact of edema after stroke and brain injury.

引用

页码：263 / 265

页数：3

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