Highly diastereoselective aziridination of α,β-unsaturated amides using diaziridine

被引：0

作者：

Ishihara, H ^{[1
]}

Ito, YN ^{[1
]}

Katsuki, T ^{[1
]}

机构：

[1] Kyushu Univ, Fac Sci, Dept Chem, Higashi Ku, Fukuoka 8128581, Japan

来源：

CHEMISTRY LETTERS | 2001年 / 10期

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Racemic 3-cyclohexyl-1-methyldiaziridine was found to react with alpha,beta -unsaturated amides in basic conditions, giving N-unprotected trans-aziridines, while 3,3-pentamethylenediaziridine had been reported to afford cis-aziridines in high diastereoselectivity. The trans-selectivity was partially dependent on the stereochemistry of the substrate. The stereochemistries of these reactions were reasonably explained by the conformational analysis of the intermediary enolates.

引用

页码：984 / 985

页数：2

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