Clinical Application of Metabolomics in Pancreatic Diseases: A Mini-Review

被引:22
作者
Gu, Wang [1 ]
Tong, Zhong [2 ]
机构
[1] Anhui Med Univ, Hefei, Peoples R China
[2] Hefei First Peoples Hosp, Hefei, Peoples R China
关键词
metabolomics; early diagnosis; pancreatic cancer (PC); acute pancreatitis (AP); chronic pancreatitis (CP); pancreatic disease; CANCER; MORTALITY; PROFILES; PERMEABILITY; LIPOPROTEIN; PATHWAY; LIPASE; POOR; RATS;
D O I
10.1093/labmed/lmz046
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Metabolomics is a powerful new analytical method to describe the set of metabolites within cellular tissue and bodily fluids. Metabolomics can uncover detailed information about metabolic changes in organisms. The morphology of these metabolites represents the metabolic processes that occur in cells, such as anabolism, catabolism, inhomogeneous natural absorption and metabolism, detoxification, and metabolism of biomass energy. Because the metabolites of different diseases are different, the specificity of the changes can be found by metabolomics testing, which provides a new source of biomarkers for the early identification of diseases and the difference between benign and malignant states. Metabolomics has a wide application potential in pancreatic diseases, including early detection, diagnosis, and identification of pancreatic diseases. However, there are few studies on metabolomics in pancreatic diseases in the literature. This article reviews the application of metabolomics in the diagnosis, prognosis, treatment, and evaluation of pancreatic diseases.
引用
收藏
页码:116 / 121
页数:6
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