Cognition-tracking-based strategies for diagnosis and treatment of minimal hepatic encephalopathy

被引：9
作者：
Han, Weijia [1 ,2 ]
Zhang, Huanqian [3 ]
Han, Ying [4 ]
Duan, Zhongping [1 ,2 ]
机构：
[1] Capital Med Univ, Beijing Youan Hosp, Difficult & Complicated Liver Dis & Artificial Li, Beijing 100069, Peoples R China
[2] Beijing Municipal Key Lab Liver Failure & Artific, Beijing, Peoples R China
[3] Yidu Cent Hosp, Weifang Med Coll, Weifang, Shandong, Peoples R China
[4] Capital Med Univ, BeijingYouAn Hosp, Dept Immunol Liver Dis, Beijing, Peoples R China
来源：
METABOLIC BRAIN DISEASE | 2020年 / 35卷 / 06期
基金：
国家重点研发计划;
关键词：
Cognitive impairment; Diagnosis and treatment; Minimal hepatic encephalopathy; Nerve cells; ORNITHINE-L-ASPARTATE; CRITICAL FLICKER FREQUENCY; QUALITY-OF-LIFE; CIRRHOTIC-PATIENTS; LIVER-CIRRHOSIS; WHITE-MATTER; TNF-ALPHA; LACTULOSE; ASTROCYTES; SAFETY;
D O I：
10.1007/s11011-020-00539-w
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Minimal hepatic encephalopathy (MHE), which shows mild cognitive impairment, is a subtle complication of cirrhosis that has been shown to affect daily functioning and quality of life. However, until 2014, relevant guidelines do not give much attention to the diagnosis and treatment of MHE, resulting in patients being ignored and denied the benefits of treatment. In this review, we summarize recent cognition-based research about (1) alteration of nerve cells, including astrocytes, microglial cells and neurons, in mild cognitive impairment in MHE; (2) comparison of methods in detecting cognitive impairment in MHE; and (3) comparison of methods for therapy of cognitive impairment in MHE. We hope to provide information about diagnosis and treatment of cognitive impairment in patients with MHE.
引用
收藏
页码：869 / 881
页数：13
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