Prognostic significance of immunohistochemical biomarkers in diffuse large B-cell lymphoma: a study from the Lunenburg Lymphoma Biomarker Consortium

被引：160

作者：

Salles, Gilles ^{[1
,2
]}

de Jong, Daphne ^{[3
]}

Xie, Wanling ^{[4
]}

Rosenwald, Andreas ^{[5
]}

Chhanabhai, Mukesh ^{[6
]}

Gaulard, Philippe ^{[7
]}

Klapper, Wolfram ^{[8
]}

Calaminici, Maria ^{[9
]}

Sander, Birgitta ^{[10
]}

Thorns, Christoph ^{[11
]}

Campo, Elias ^{[12
]}

Molina, Thierry ^{[13
]}

Lee, Abigail ^{[9
]}

Pfreundschuh, Michael ^{[14
]}

Horning, Sandra ^{[15
]}

Lister, Andrew ^{[9
]}

Sehn, Laurie H. ^{[6
]}

Raemaekers, John ^{[16
]}

Hagenbeek, Anton ^{[17
]}

Gascoyne, Randy D. ^{[6
]}

Weller, Edie ^{[4
]}

机构：

[1] Hosp Civils Lyon, Lyon, France

[2] Univ Lyon 1, Lyon, France

[3] Netherlands Canc Inst, Amsterdam, Netherlands

[4] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA USA

[5] Univ Wurzburg, Inst Pathol, D-8700 Wurzburg, Germany

[6] Univ British Columbia, Dept Pathol & Med Oncol, BC Canc Agcy, Vancouver, BC V5Z 1M9, Canada

[7] Hop Henri Mondor, Dept Pathol, F-94010 Creteil, France

[8] Univ Hosp Schleswig Holstein, Hematopathol Sect, Dept Pathol, Kiel, Germany

[9] St Bartholomews Hosp, Canc Res UK Med Oncol Unit, London, England

[10] Karolinska Inst, Stockholm, Sweden

[11] Univ Klinkum Schleswig Holstein, Dept Pathol, Lubeck, Germany

[12] Univ Barcelona, Hosp Clin, Barcelona, Spain

[13] Univ Paris 05, Assistance Publ Hop Paris, Paris, France

[14] Univ Saarland, Dept Internal Med 1, D-6650 Homburg, Germany

[15] Stanford Univ, Med Ctr, Dept Med, Palo Alto, CA 94304 USA

[16] Radboud Univ Nijmegen, Med Ctr, Dept Hematol, Nijmegen, Netherlands

[17] Univ Amsterdam, Acad Med Ctr, Dept Haematol, NL-1105 AZ Amsterdam, Netherlands

来源：

BLOOD | 2011年 / 117卷 / 26期

关键词：

CHEMOTHERAPY PLUS RITUXIMAB; 3-WEEKLY CHOP CHEMOTHERAPY; NON-HODGKINS-LYMPHOMA; GERMINAL CENTER; ELDERLY-PATIENTS; TISSUE MICROARRAY; PREDICTS SURVIVAL; R-CHOP; AGGRESSIVE LYMPHOMAS; EXPRESSION PREDICTS;

D O I：

10.1182/blood-2011-04-345256

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The Lunenburg Lymphoma Biomarker Consortium (LLBC) evaluated the prognostic value of IHC biomarkers in a large series of patients with diffuse large B-cell lymphoma (DLBCL). Clinical data and tumor samples were retrieved from 12 studies from Europe and North America, with patients treated before or after the rituximab era. Using tissue microarrays from 1514 patients, IHC for BCL2, BCL6, CD5, CD10, MUM1, Ki67, and HLA-DR was performed and scored according to previously validated protocols. Optimal cut points predicting overall survival of patients treated in the rituximab era could only be determined for CD5 (P = .003) and Ki67 (P = .02), whereas such cut points for BCL2, BCL6, HLA-DR, and MUM1 could only be defined in patients not receiving rituximab. A prognostic model for patients treated in the rituximab era identified 4 risk groups using BCL2, Ki67, and International Prognostic Index (IPI) with improved discrimination of low-risk patients. Newly recognized correlations between specific biomarkers and IPI highlight the importance of carefully controlling for clinical and biologic factors in prognostic models. These data demonstrate that the IPI remains the best available index in patients with DLBCL treated with rituximab and chemotherapy. (Blood. 2011;117(26):7070-7078)

引用

页码：7070 / 7078

页数：9

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