Briarane Diterpenes Diminish COX-2 Expression in Human Colon Adenocarcinoma Cells

被引：10

作者：

Joyner, P. Matthew ^{[1
]}

Waters, Amanda L. ^{[1
]}

Williams, Russell B. ^{[1
]}

Powell, Douglas R. ^{[1
]}

Janakiram, Naveena B. ^{[2
]}

Rao, Chinthalapally V. ^{[2
]}

Cichewicz, Robert H. ^{[1
,3
]}

机构：

[1] Univ Oklahoma, Nat Prod Discovery Grp, Dept Chem & Biochem, Stephenson Life Sci Res Ctr, Norman, OK 73019 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Univ Oklahoma Canc Inst, Dept Med, Oklahoma City, OK 73104 USA

[3] Univ Oklahoma, Grad Program Ecol & Evolutionary Biol, Norman, OK 73019 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 04期

关键词：

STATISTICS; CORALS;

D O I：

10.1021/np100775a

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Exploration of a soft Coral (Briareum sp.) from Vanuatu led to the isolation Of three new briaranes, designated brialalepolidei A(1), B (2), and C (3). Compounds 2 and 3 reduced the expression of COX-2 inhuman colon adenocarcinoma cells, as Well as in murine macrophage cells. This is significant because the metabolic products of COX-2 have been implicated in the pathogenesis of colon cancer and other diseases.

引用

页码：857 / 861

页数：5

共 15 条

[1]

[Anonymous], INTRO CELL TISSUE CU

[2] STUDIES OF AUSTRALIAN SOFT CORALS .46. NEW DITERPENES FROM A BRIAREUM SPECIES (ANTHOZOA, OCTOCORALLIA, GORGONACEA) [J].