CD8+ T Cells: Foot Soldiers of the Immune System

被引:749
作者
Zhang, Nu [1 ,2 ]
Bevan, Michael J. [1 ,2 ]
机构
[1] Univ Washington, Dept Immunol, Seattle, WA 98195 USA
[2] Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA
关键词
CHRONIC VIRAL-INFECTION; INFLUENZA-VIRUS INFECTION; IN-VITRO CYTOTOXICITY; LYMPH-NODES; TRANSCRIPTION FACTORS; DENDRITIC CELLS; LYMPHOCYTIC CHORIOMENINGITIS; EFFECTOR FUNCTION; MAMMALIAN TARGET; IL-10; PRODUCTION;
D O I
10.1016/j.immuni.2011.07.010
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Resting naive CD8(+) T cells have an astounding capacity to react to pathogens by massive expansion and differentiation into cytotoxic effector cells that migrate to all corners of the body to clear the infection. The initial interaction with antigen-presenting cells in the central lymphoid organs drives an orchestrated program of differentiation aimed at producing sufficient numbers of effectors to get the job done without resulting in clonal exhaustion. Interactions with antigen-presenting cells and other immune cells continue at the site of infection to regulate further on-site expansion and differentiation, all with the goal of protecting the host with minimal bystander tissue damage. Here we review recent advances in CD8(+) T cell recognition of antigen in lymphoid as well as in nonlymphoid tissues in the periphery, and how CD8(+) T cell expansion and differentiation are controlled in these contexts.
引用
收藏
页码:161 / 168
页数:8
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