Prediction of pathological complete response to neoadjuvant chemotherapy by magnetic resonance imaging in breast cancer patients

被引：26

作者：

Michishita, Shintaro ^{[1
]}

Kim, Seung Jin ^{[1
]}

Shimazu, Kenzo ^{[1
]}

Sota, Yoshiaki ^{[1
]}

Naoi, Yasuto ^{[1
]}

Maruyama, Naomi ^{[1
]}

Kagara, Naofumi ^{[1
]}

Shimoda, Masafumi ^{[1
]}

Shimomura, Atsushi ^{[1
]}

Noguchi, Shinzaburo ^{[1
]}

机构：

[1] Osaka Univ, Dept Breast & Endocrine Surg, Grad Sch Med, Suita, Osaka 5650871, Japan

来源：

BREAST | 2015年 / 24卷 / 02期

基金：

日本学术振兴会;

关键词：

MRI morphology; Neoadjuvant chemotherapy; pCR; Predictor; Intrinsic subtype; SURGICAL ADJUVANT BREAST; CONTRAST-ENHANCED MRI; PREOPERATIVE CHEMOTHERAPY; TUMOR RESPONSE; INTRINSIC SUBTYPES; CYCLOPHOSPHAMIDE; THERAPY; DOXORUBICIN; PACLITAXEL; PARAMETERS;

D O I：

10.1016/j.breast.2015.01.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The purpose of this study was to evaluate whether the baseline breast MRI findings would be useful for the prediction for pathological complete response (pCR) by breast cancer patients to neoadjuvant chemotherapy. Primary breast cancer patients (stage II-III) preoperatively treated with sequential paclitaxel (12 cycles) and fluorouracil, epirubicin, and cyclophosphamide (4 cycles), followed by surgery were retrospectively enrolled, and 229 patients were eligible. Before chemotherapy, breast MRI studies were performed. Breast tumors were dichotomized into round + oval and irregular types based on MRI morphology. The round + oval tumors showed a significantly higher pCR rate than the irregular tumors (42.0% vs 17.3%; P < 0.001). In addition, PAM50 analysis revealed that basal and HER2-enriched tumors were significantly more prevalent among round + oval than irregular type tumors (P = 0.015). Baseline MRI morphology appears to be a significant predictor for pCR. The higher rate of the basal and HER2-enriched tumors among the round + oval tumors may explain their better chemo-sensitivity. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：159 / 165

页数：7

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