Synthesis and antibacterial activities of cadiolides A, B and C and analogues

被引：20

作者：

Boulange, Agathe ^{[1
,2
]}

Parraga, Javier ^{[3
]}

Galan, Abraham ^{[3
]}

Cabedo, Nuria ^{[3
,4
]}

Leleu, Stephane ^{[1
,2
]}

Jesus Sanz, Maria ^{[5
,6
]}

Cortes, Diego ^{[3
]}

Franck, Xavier ^{[1
,2
]}

机构：

[1] Normandie Univ, COBRA, UMR 6014, F-76821 Mont St Aignan, France

[2] Univ Rouen, CNRS, FR 3038, INSA Rouen, F-76821 Mont St Aignan, France

[3] Univ Valencia, Fac Farm, Dept Farmacol, Valencia 46100, Spain

[4] Univ Politecn Valencia, Inst Agroforestal Mediterraneo, Ctr Ecol Quim Agr, Valencia 46022, Spain

[5] Univ Valencia, Fac Med, Dept Farmacol, Valencia 46010, Spain

[6] Univ Clin Hosp Valencia, Inst Hlth Res INCLIVA, Valencia 46010, Spain

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2015年 / 23卷 / 13期

关键词：

Cadiolides; Antibacterial; Butenolides; Multicomponent; Natural products; ASCIDIAN SYNOICUM SP; ANTIBIOTIC-RESISTANCE; ANTIMICROBIAL AGENTS; RUBROLIDES; TUNICATE; METABOLITES; APOPTOSIS; FURANONE; CELLS;

D O I：

10.1016/j.bmc.2015.04.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The one-pot multicomponent synthesis of natural butenolides named cadiolides A, B, C and analogues has been realized. The antibacterial structure activity relationship shows that the presence of phenolic hydroxyl groups and the number and position of bromine atoms on the different aromatic rings are important features for antibacterial activity, besides it was demonstrated the tolerance of both benzene and furan ring at position 3 of the butenolide nucleus. Furthermore, none of the most relevant antibacterial compounds showed any cytotoxicity in freshly isolated human neutrophils. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：3618 / 3628

页数：11

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