The anticancer dolastatins as cyanobacterial metabolites

被引：5

作者：

Harrigan, GG ^{[1
]}

Luesch, H ^{[1
]}

Moore, RE ^{[1
]}

Paul, VJ ^{[1
]}

机构：

[1] Searle Discovery Res, Chesterfield, MO 63198 USA

来源：

BIODIVERSITY: NEW LEADS FOR THE PHARMACEUTICAL AND AGROCHEMICAL INDUSTRIES | 2000年 / 257期

关键词：

D O I：

10.1039/9781847550231-00126

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several analogues of the dolastatins, potent cytotoxic compounds originally derived from the Indian Ocean seahare, Dolabella auricularia, have now been found in the marine cyanobacteria, Lyngbya majuscula and Symploca hydnoides. These discoveries support the proposal that the dolastatins isolated from D. auricularia are of dietary origin. The implications of such an observation to natural products programmes is discussed. Aspects of the structure elucidation of these complex molecules are also presented.

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页码：126 / 139

页数：14

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