Oxcarbazepine: structure and anticonvulsant activity

被引：20

作者：

Hempel, A

Camerman, N

Camerman, A

Mastropaolo, D

机构：

[1] Univ Toronto, Dept Biochem, Toronto, ON M5S 1A8, Canada

[2] Ardono Res, Bellevue, WA 98004 USA

来源：

ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS | 2005年 / 61卷

关键词：

D O I：

10.1107/S1600536805010676

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

In the crystal structure of the title compound, 10-oxo-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide, C15H12N2O2, the azepine seven-membered ring adopts a classical but slightly twisted boat conformation, forcing the molecule to adopt a butterfly shape. In addition to one normal hydrogen bond, two non-standard weak hydrogen bonds of the C-H center dot center dot center dot O type also contribute to the molecular arrangement in the crystal structure. Stereochemical comparison with phenytoin indicates that oxcarbazepine may utilize the same mechanism for its anticonvulsant activity.

引用

收藏

页码：O1313 / O1315

页数：3

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