Long-term surgical and patient-reported outcomes of Hirschsprung Disease

被引:48
作者
Davidson, Joseph R. [1 ,2 ]
Kyrklund, Kristiina [3 ,4 ]
Eaton, Simon [2 ]
Pakarinen, Mikko P. [3 ,4 ]
Thompson, David S. [1 ]
Cross, Kate [1 ]
Blackburn, Simon C. [1 ]
De Coppi, Paolo [1 ,2 ]
Curry, Joe [1 ]
机构
[1] Great Ormond St Hosp Sick Children, Neonatal & Paediat Surg, London WC1N 3JH, England
[2] UCL GOS Inst Child Hlth, Stem Cells & Regenerat Med Sect, London, England
[3] Univ Helsinki, New Childrens Hosp, Dept Paediat Surg, Helsinki, Finland
[4] Helsinki Univ Hosp, Helsinki, Finland
关键词
Hirschsprung's; Duhamel; Long-term outcomes; Quality of life; Bowel function; QUALITY-OF-LIFE; HEALTH SURVEY QUESTIONNAIRE; ENDORECTAL PULL-THROUGH; URINARY-TRACT SYMPTOMS; BOWEL FUNCTION; FOLLOW-UP; CONTINENCE; CHILDHOOD; SURGERY; ADULTS;
D O I
10.1016/j.jpedsurg.2021.01.043
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Background: Information is needed regarding the complex relationships between long-term functional outcomes and health-related quality of life (HRQoL) in Hirschsprung's Disease (HSCR). We describe longterm outcomes across multiple domains, completing a core outcome set through to adulthood. Methods: HSCR patients operated at a single center over a 35-year period (1978-2013) were studied. Patients completed detailed questionnaires on bowel and urologic function, and HRQOL. Patients with learning disability (LD) were excluded. Outcomes were compared to normative data. Data are reported as median [IQR] or mean (SD). Results: 186 patients (median age 28 [18-32] years; 135 males) completed surveys. Bowel function was reduced (BFS 17 [14-19] vs. 19 [19-20], p < 0.0001;eta(2) = 0.22). Prevalence and severity of fecal soiling and fecal awareness improved with age ( p < 0.05 for both). Urinary incontinence was more frequent than controls, most of all in 13-26y females (65% vs. 31%, p = 0.003). In adults, this correlated independently with constipation symptoms (OR 3.18 [1.4-7.5], p = 0.008). HRQoL outcomes strongly correlated with functional outcome: 42% of children demonstrated clinically significant reductions in overall PedsQL score, and poor bowel outcome was strongly associated with impaired QOL (B = 22.7 [12.7- 32.7], p < 0.001). In adults, GIQLI scores were more often impacted in patients with extended segment disease. SF-36 scores were reduced relative to population level data in most domains, with large effect sizes noted for females in General Health (g = 1.19) and Social Wellbeing (g = 0.8). Conclusion: Functional impairment is common after pull-through, but bowel function improves with age. Clustering of poor functional outcomes across multiple domains identifies a need for early recognition and long-term support for these patients. (C) 2021 Elsevier Inc. All rights reserved.
引用
收藏
页码:1502 / 1511
页数:10
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