Mismatch repair deficiency in sporadic synchronous colorectal cancer

被引:0
作者
Brueckl, WM
Limmert, T
Brabletz, T
Guenther, K
Jung, A
Hermann, K
Wiest, GH
Kirchner, T
Hohenberger, W
Hahn, EG
Wein, A
机构
[1] Univ Erlangen Nurnberg, Dept Internal Med 1, D-91054 Erlangen, Germany
[2] Univ Erlangen Nurnberg, Dept Pathol, D-91054 Erlangen, Germany
[3] Univ Erlangen Nurnberg, Dept Surg, D-91054 Erlangen, Germany
关键词
HNPCC; synchronous colorectal cancer (SCRC); DNA mismatch repair (MMR); microsatellite instability (MSI);
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Hereditary non-polyposis colorectal cancer (HNPCC) patients frequently develop synchronous colorectal cancer (SCRC) which also occurs sporadically in other patients. Recent studies on microsatellite instability (MSI) in sporadic SCRC diverge completely in their findings (0%-100%). In the present study MSI and mismatch repair (MMR) proteins were evaluated according to standardised criteria (exclusion of a family history, MSI analysed according to NCI recommendations) Methods: Paraffin embedded sections of SCRC of 30 patients were evaluated for MSI and the loss of protein expression of hMLH1 and hMSH2. Results: 3 out of 30 (10%) patients exhibited MSI-H which 5 out of 30 (17%) showed MSI-L. Loss of protein expression of either hMLH1 or hMSH2 was found in all cases of MSI-H and none of the MSI-L cancers. Conclusion: MSI is found in sporadic cases of SCRC to about the same extent as it is mentioned in the literature on sporadic single colorectal cancers. Immunohistochemistry with mismatch repair proteins could be used as a pre-screening for MMR deficiency in sporadic SCRC.
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收藏
页码:4727 / 4732
页数:6
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