Effects induced by a 50 HZ electromagnetic field and doxorubicin on Walker-256 carcinosarcoma growth and hepatic redox state in rats

被引：4

作者：

Orel, Valerii E. ^{[1
,2
]}

Krotevych, Mykhailo ^{[3
]}

Dasyukevich, Olga ^{[1
]}

Rykhalskyi, Oleksandr ^{[1
]}

Syvak, Liubov ^{[4
]}

Tsvir, Helena

Tsvir, Dmytro ^{[5
]}

Garmanchuk, Lyudmyla ^{[6
]}

Orel, Valerii B. ^{[2
,7
]}

Sheina, Iryna ^{[8
]}

Rybka, Vladyslava ^{[9
]}

Shults, Nataliia V. ^{[8
]}

Suzuki, Yuichiro J. ^{[9
]}

Gychka, Sergiy G. ^{[10
]}

机构：

[1] Natl Canc Inst, Med Phys & Bioengn Res Lab, 33-43 Lomonosov Str, UA-03022 Kiev, Ukraine

[2] NTUU Igor Sikorsky KPI, Biomed Engn Dept, Kiev, Ukraine

[3] Natl Canc Inst, Res Dept Pathol Anat, Kiev, Ukraine

[4] Bogomolets Natl Canc Inst, Res Dept Chemotherapy Solid Tumors, Kiev, Ukraine

[5] Bogomolets Natl Med Univ, Med Fac, Kharkiv, Ukraine

[6] Kyiv Natl Taras Shevchenko Univ, NSC Inst Biol & Med Inst, Dept Biomed, Kiev, Ukraine

[7] Natl Canc Inst, Res Dept Radiodiagnost, Kiev, Ukraine

[8] Kharkov Natl Univ, Dept Med Phys & Biomed Nanotechnol, Kiev, Ukraine

[9] Georgetown Univ, Med Ctr, Dept Pharmacol & Physiol, Washington, DC 20007 USA

[10] Bogomolets Natl Med Univ, Dept Pathol Anat 2, Kiev, Ukraine

来源：

ELECTROMAGNETIC BIOLOGY AND MEDICINE | 2021年 / 40卷 / 04期

关键词：

Electromagnetic field; doxorubicin; Walker-256; carcinosarcoma; oxidative stress; hepatic redox state; OXIDATIVE STRESS; MAGNETIC-FIELD; CANCER; TUMOR; LIVER; ANTIOXIDANTS; EXPOSURE; ROS; RADIATION; GLUTATHIONE;

D O I：

10.1080/15368378.2021.1958342

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We compare the effects of an extremely low-frequency electromagnetic field (EMF) with the chemotherapeutic agent doxorubicin (DOX) on tumor growth and the hepatic redox state in Walker-256 carcinosarcoma-bearing rats. Animals were divided into five groups with one control (no tumor) and four tumor-bearing groups: no treatment, DOX, DOX combined with EMF and EMF. While DOX and DOX + EMF provided greater inhibition of tumor growth, treatment with EMF alone resulted in some level of antitumor effect (p < .05). Superoxide dismutase, catalase activity and glutathione content were significantly decreased in the liver of tumor-bearing animals as compared with the control group (p < .05). The decreases in antioxidant defenses accompanied histological findings of suspected liver damage. However, hepatic levels of thiobarbituric acid reactive substances, an indicator of lipid peroxidation, were three times lower in EMF and DOX + EMF groups than in no treatment and DOX (p < .05). EMF and DOX + EMF showed significantly lower activity of serum ALT than DOX alone (p < .05). These results indicate that EMF treatment can inhibit tumor growth, causing less pronounced oxidative stress damage to the liver. Therefore, EMF can be used as a therapeutic strategy to influence the hepatic redox state and combat cancer with reduced side-effects.

引用

页码：475 / 487

页数：13

共 81 条

[1] Ruthenium complex exerts antineoplastic effects that are mediated by oxidative stress without inducing toxicity in Walker-256 tumor-bearing rats [J].