Nanomaterials as Inhibitors of Epithelial Mesenchymal Transition in Cancer Treatment

被引：27

作者：

Cordani, Marco ^{[1
]}

Strippoli, Raffaele ^{[2
,3
]}

Somoza, Alvaro ^{[1
,4
]}

机构：

[1] Inst Madrileno Estudios Avanzados Nanociencia IMD, Madrid 28049, Spain

[2] Sapienza Univ Rome, Dept Mol Med, I-00161 Rome, Italy

[3] Natl Inst Infect Dis Lazzaro Spallanzani IRCCS, I-00149 Rome, Italy

[4] CSIC, IMDEA, CNB, Nanociencia Associated Unit,Unidad Nanobiotecnol, Madrid 28049, Spain

来源：

CANCERS | 2020年 / 12卷 / 01期

关键词：

nanomaterials; nanomedicine; epithelial-mesenchymal transition; cancer metastasis; cancer therapy; CERIUM OXIDE NANOPARTICLES; WALLED CARBON NANOTUBES; SMALL INTERFERING RNA; NOGO-B RECEPTOR; PANCREATIC-CANCER; GOLD NANOPARTICLES; HEPATOCELLULAR-CARCINOMA; SELENIUM NANOPARTICLES; DRUG-RESISTANCE; BREAST-CANCER;

D O I：

10.3390/cancers12010025

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epithelial-mesenchymal transition (EMT) has emerged as a key regulator of cell invasion and metastasis in cancers. Besides the acquisition of migratory/invasive abilities, the EMT process is tightly connected with the generation of cancer stem cells (CSCs), thus contributing to chemoresistance. However, although EMT represents a relevant therapeutic target for cancer treatment, its application in the clinic is still limited due to various reasons, including tumor-stage heterogeneity, molecular-cellular target specificity, and appropriate drug delivery. Concerning this last point, different nanomaterials may be used to counteract EMT induction, providing novel therapeutic tools against many different cancers. In this review, (1) we discuss the application of various nanomaterials for EMT-based therapies in cancer, (2) we summarize the therapeutic relevance of some of the proposed EMT targets, and (3) we review the potential benefits and weaknesses of each approach.

引用

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