The human microRNA 452 (MIR452) was identified as a colorectal cancer (CRC)-associated micro RNA (miRNA) by miRNA expression profiling of human CRC tissues versus normal colorectal tissues. It was significantly up-regulated in human CRC tissues. However, the functional mechanisms of MIR452 and its target genes in CRC remain unclear. We identified 27 putative MIR452 target genes, and found that the vascular endothelial growth factor A (VEGFA) was a direct target gene of MIR452. Both cellular and extracellular VEGFA levels were significantly downregulated in CRC cells upon their transfection with MIR452 or siVEGFA. VEGFA expression was frequently downregulated in human CRC tissues in comparison with that in their healthy counterparts. We showed that MIR452 regulated the expression of genes in the VEGFA-mediated signal transduction pathways vascular endothelial growth factor receptor 1 (VEGFR2)-mitogen-activated protein kinase (MAPK) and VEGFR2-SRC proto-oncogene non-receptor tyrosine kinase (SRC) in CRC cells. Immunohistological analyses of xenografted MIR452-overexpressing CRC cells in mice showed that MIR452 regulated cell proliferation and angiogenesis. Furthermore, aortic ring angiogenesis assay in rats clearly showed that the number of microvessels formed was significantly reduced by MIR452 transfection. Our findings suggest that MIR452 regulates cell proliferation, cell migration, and angiogenesis by suppressing VEGFA expression in early CRC progression; therefore, MIR452 may have therapeutic value in relation to human CRC.
机构:
Weifang Med Univ, Clin Med Coll, 7166 Baotong Rd West, Weifang 261053, Shandong, Peoples R ChinaWeifang Med Univ, Clin Med Coll, 7166 Baotong Rd West, Weifang 261053, Shandong, Peoples R China
Ding, Na
Li, Rongxin
论文数: 0引用数: 0
h-index: 0
机构:
Weifang Med Univ, Dept Pharm, Affiliated Hosp, 2428 Yuhe Rd, Weifang 261031, Shandong, Peoples R ChinaWeifang Med Univ, Clin Med Coll, 7166 Baotong Rd West, Weifang 261053, Shandong, Peoples R China
Li, Rongxin
Shi, Wenhao
论文数: 0引用数: 0
h-index: 0
机构:
Binzhou Med Univ, Clin Med Coll, 346 Guanhai Rd, Yantai 264003, Shandong, Peoples R ChinaWeifang Med Univ, Clin Med Coll, 7166 Baotong Rd West, Weifang 261053, Shandong, Peoples R China
Shi, Wenhao
He, Cui
论文数: 0引用数: 0
h-index: 0
机构:
Weifang Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp, 2428 Yuhe Rd, Weifang 261031, Shandong, Peoples R ChinaWeifang Med Univ, Clin Med Coll, 7166 Baotong Rd West, Weifang 261053, Shandong, Peoples R China
机构:
Korea Res Inst Biosci & Biotechnol, Biotherapeut Translat Res Ctr, Div Biomed Sci, Daejeon 34141, South Korea
Univ Sci & Technol, Dept Funct Genom, Daejeon 34141, South KoreaKorea Res Inst Biosci & Biotechnol, Biotherapeut Translat Res Ctr, Div Biomed Sci, Daejeon 34141, South Korea
Hwang, Jin-Seong
Jeong, Eun-Jeong
论文数: 0引用数: 0
h-index: 0
机构:
Korea Res Inst Biosci & Biotechnol, Biotherapeut Translat Res Ctr, Div Biomed Sci, Daejeon 34141, South Korea
Wonkwang Univ, Coll Nat Sci, Dept Biol Sci, Iksan 570450, South KoreaKorea Res Inst Biosci & Biotechnol, Biotherapeut Translat Res Ctr, Div Biomed Sci, Daejeon 34141, South Korea
Jeong, Eun-Jeong
Choi, Jinhyeon
论文数: 0引用数: 0
h-index: 0
机构:
Korea Res Inst Biosci & Biotechnol, Biotherapeut Translat Res Ctr, Div Biomed Sci, Daejeon 34141, South KoreaKorea Res Inst Biosci & Biotechnol, Biotherapeut Translat Res Ctr, Div Biomed Sci, Daejeon 34141, South Korea
Choi, Jinhyeon
Lee, Yeo-Jin
论文数: 0引用数: 0
h-index: 0
机构:
Korea Res Inst Biosci & Biotechnol, Biotherapeut Translat Res Ctr, Div Biomed Sci, Daejeon 34141, South Korea
Univ Sci & Technol, Dept Funct Genom, Daejeon 34141, South KoreaKorea Res Inst Biosci & Biotechnol, Biotherapeut Translat Res Ctr, Div Biomed Sci, Daejeon 34141, South Korea
Lee, Yeo-Jin
Jung, Eunsun
论文数: 0引用数: 0
h-index: 0
机构:
Korea Res Inst Biosci & Biotechnol, Biotherapeut Translat Res Ctr, Div Biomed Sci, Daejeon 34141, South KoreaKorea Res Inst Biosci & Biotechnol, Biotherapeut Translat Res Ctr, Div Biomed Sci, Daejeon 34141, South Korea
Jung, Eunsun
Kim, Seon-Kyu
论文数: 0引用数: 0
h-index: 0
机构:
Korea Res Inst Biosci & Biotechnol, Personalized Genom Med Res Ctr, Div Biomed Sci, Daejeon 34141, South KoreaKorea Res Inst Biosci & Biotechnol, Biotherapeut Translat Res Ctr, Div Biomed Sci, Daejeon 34141, South Korea
Kim, Seon-Kyu
论文数: 引用数:
h-index:
机构:
Min, Jeong-Ki
Han, Tae-Su
论文数: 0引用数: 0
h-index: 0
机构:
Korea Res Inst Biosci & Biotechnol, Biotherapeut Translat Res Ctr, Div Biomed Sci, Daejeon 34141, South KoreaKorea Res Inst Biosci & Biotechnol, Biotherapeut Translat Res Ctr, Div Biomed Sci, Daejeon 34141, South Korea
Han, Tae-Su
Kim, Jang-Seong
论文数: 0引用数: 0
h-index: 0
机构:
Korea Res Inst Biosci & Biotechnol, Biotherapeut Translat Res Ctr, Div Biomed Sci, Daejeon 34141, South Korea
Univ Sci & Technol, Dept Funct Genom, Daejeon 34141, South KoreaKorea Res Inst Biosci & Biotechnol, Biotherapeut Translat Res Ctr, Div Biomed Sci, Daejeon 34141, South Korea
机构:
Beibei Tradit Chinese Med Hosp, Dept Gen Surg, Chongqing, Peoples R ChinaBeibei Tradit Chinese Med Hosp, Dept Gen Surg, Chongqing, Peoples R China
Huang, Long
Dai, Gang
论文数: 0引用数: 0
h-index: 0
机构:
Fengdu Peoples Hosp, Dept Gen Surg, 214 Pingdu Ave, Chongqing 408200, Peoples R ChinaBeibei Tradit Chinese Med Hosp, Dept Gen Surg, Chongqing, Peoples R China
机构:
Soochow Univ, Sch Biol & Basic Med Sci, Suzhou 215213, Jiangsu, Peoples R China
Peking Univ China, Grad Sch, Japan Friendship Sch Clin Med, Beijing 100029, Peoples R China
Chinese Acad Med Sci & Peking Union Med Coll, Grad Sch, Beijing 100029, Peoples R ChinaSoochow Univ, Sch Biol & Basic Med Sci, Suzhou 215213, Jiangsu, Peoples R China
Zhao, Dong-Yan
Yin, Teng-Fei
论文数: 0引用数: 0
h-index: 0
机构:
Shandong Univ, Dept Gastroenterol, Qilu Hosp, Jinan 250012, Shandong, Peoples R ChinaSoochow Univ, Sch Biol & Basic Med Sci, Suzhou 215213, Jiangsu, Peoples R China
Yin, Teng-Fei
Sun, Xi-Zhen
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Jishuitan Hosp, Dept Gastroenterol, Beijing 100035, Peoples R ChinaSoochow Univ, Sch Biol & Basic Med Sci, Suzhou 215213, Jiangsu, Peoples R China
Sun, Xi-Zhen
Zhou, Yuan-Chen
论文数: 0引用数: 0
h-index: 0
机构:
China Japan Friendship Hosp, Dept Gastroenterol, Beijing 100029, Peoples R ChinaSoochow Univ, Sch Biol & Basic Med Sci, Suzhou 215213, Jiangsu, Peoples R China
Zhou, Yuan-Chen
Wang, Qian-Qian
论文数: 0引用数: 0
h-index: 0
机构:
China Japan Friendship Hosp, Dept Gastroenterol, Beijing 100029, Peoples R China
Peking Univ China, Grad Sch, Japan Friendship Sch Clin Med, Beijing 100029, Peoples R ChinaSoochow Univ, Sch Biol & Basic Med Sci, Suzhou 215213, Jiangsu, Peoples R China
Wang, Qian-Qian
Zhou, Ge-Yujia
论文数: 0引用数: 0
h-index: 0
机构:
China Japan Friendship Hosp, Dept Gastroenterol, Beijing 100029, Peoples R ChinaSoochow Univ, Sch Biol & Basic Med Sci, Suzhou 215213, Jiangsu, Peoples R China
Zhou, Ge-Yujia
Yao, Shu-Kun
论文数: 0引用数: 0
h-index: 0
机构:
China Japan Friendship Hosp, Dept Gastroenterol, Beijing 100029, Peoples R China
China Japan Friendship Hosp, Dept Gastroenterol, 2 Yinghua East Rd, Beijing 100029, Peoples R ChinaSoochow Univ, Sch Biol & Basic Med Sci, Suzhou 215213, Jiangsu, Peoples R China
机构:
School of Biology&Basic Medical Sciences,Soochow UniversitySchool of Biology&Basic Medical Sciences,Soochow University
Dong-Yan Zhao
Teng-Fei Yin
论文数: 0引用数: 0
h-index: 0
机构:
Department of Gastroenterology,Qilu Hospital of Shandong UniversitySchool of Biology&Basic Medical Sciences,Soochow University
Teng-Fei Yin
Xi-Zhen Sun
论文数: 0引用数: 0
h-index: 0
机构:
Department of Gastroenterology,Beijing Jishuitan HospitalSchool of Biology&Basic Medical Sciences,Soochow University
Xi-Zhen Sun
Yuan-Chen Zhou
论文数: 0引用数: 0
h-index: 0
机构:
Department of Gastroenterology,China-Japan Friendship Hospital
Graduate School,Peking University China-Japan Friendship School of Clinical MedicineSchool of Biology&Basic Medical Sciences,Soochow University
Yuan-Chen Zhou
Qian-Qian Wang
论文数: 0引用数: 0
h-index: 0
机构:
Department of Gastroenterology,China-Japan Friendship Hospital
Graduate School,Peking University China-Japan Friendship School of Clinical MedicineSchool of Biology&Basic Medical Sciences,Soochow University
Qian-Qian Wang
Ge-Yujia Zhou
论文数: 0引用数: 0
h-index: 0
机构:
Department of Gastroenterology,China-Japan Friendship Hospital
Graduate School,Chinese Academy of Medical Sciences and Peking Union Medical CollegeSchool of Biology&Basic Medical Sciences,Soochow University
Ge-Yujia Zhou
Shu-Kun Yao
论文数: 0引用数: 0
h-index: 0
机构:
Department of Gastroenterology,China-Japan Friendship HospitalSchool of Biology&Basic Medical Sciences,Soochow University
机构:
Weifang Med Univ, Clin Med Coll, 7166 Baotong Rd West, Weifang 261053, Shandong, Peoples R ChinaWeifang Med Univ, Clin Med Coll, 7166 Baotong Rd West, Weifang 261053, Shandong, Peoples R China
Ding, Na
Li, Rongxin
论文数: 0引用数: 0
h-index: 0
机构:
Weifang Med Univ, Dept Pharm, Affiliated Hosp, 2428 Yuhe Rd, Weifang 261031, Shandong, Peoples R ChinaWeifang Med Univ, Clin Med Coll, 7166 Baotong Rd West, Weifang 261053, Shandong, Peoples R China
Li, Rongxin
Shi, Wenhao
论文数: 0引用数: 0
h-index: 0
机构:
Binzhou Med Univ, Clin Med Coll, 346 Guanhai Rd, Yantai 264003, Shandong, Peoples R ChinaWeifang Med Univ, Clin Med Coll, 7166 Baotong Rd West, Weifang 261053, Shandong, Peoples R China
Shi, Wenhao
He, Cui
论文数: 0引用数: 0
h-index: 0
机构:
Weifang Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp, 2428 Yuhe Rd, Weifang 261031, Shandong, Peoples R ChinaWeifang Med Univ, Clin Med Coll, 7166 Baotong Rd West, Weifang 261053, Shandong, Peoples R China
机构:
Korea Res Inst Biosci & Biotechnol, Biotherapeut Translat Res Ctr, Div Biomed Sci, Daejeon 34141, South Korea
Univ Sci & Technol, Dept Funct Genom, Daejeon 34141, South KoreaKorea Res Inst Biosci & Biotechnol, Biotherapeut Translat Res Ctr, Div Biomed Sci, Daejeon 34141, South Korea
Hwang, Jin-Seong
Jeong, Eun-Jeong
论文数: 0引用数: 0
h-index: 0
机构:
Korea Res Inst Biosci & Biotechnol, Biotherapeut Translat Res Ctr, Div Biomed Sci, Daejeon 34141, South Korea
Wonkwang Univ, Coll Nat Sci, Dept Biol Sci, Iksan 570450, South KoreaKorea Res Inst Biosci & Biotechnol, Biotherapeut Translat Res Ctr, Div Biomed Sci, Daejeon 34141, South Korea
Jeong, Eun-Jeong
Choi, Jinhyeon
论文数: 0引用数: 0
h-index: 0
机构:
Korea Res Inst Biosci & Biotechnol, Biotherapeut Translat Res Ctr, Div Biomed Sci, Daejeon 34141, South KoreaKorea Res Inst Biosci & Biotechnol, Biotherapeut Translat Res Ctr, Div Biomed Sci, Daejeon 34141, South Korea
Choi, Jinhyeon
Lee, Yeo-Jin
论文数: 0引用数: 0
h-index: 0
机构:
Korea Res Inst Biosci & Biotechnol, Biotherapeut Translat Res Ctr, Div Biomed Sci, Daejeon 34141, South Korea
Univ Sci & Technol, Dept Funct Genom, Daejeon 34141, South KoreaKorea Res Inst Biosci & Biotechnol, Biotherapeut Translat Res Ctr, Div Biomed Sci, Daejeon 34141, South Korea
Lee, Yeo-Jin
Jung, Eunsun
论文数: 0引用数: 0
h-index: 0
机构:
Korea Res Inst Biosci & Biotechnol, Biotherapeut Translat Res Ctr, Div Biomed Sci, Daejeon 34141, South KoreaKorea Res Inst Biosci & Biotechnol, Biotherapeut Translat Res Ctr, Div Biomed Sci, Daejeon 34141, South Korea
Jung, Eunsun
Kim, Seon-Kyu
论文数: 0引用数: 0
h-index: 0
机构:
Korea Res Inst Biosci & Biotechnol, Personalized Genom Med Res Ctr, Div Biomed Sci, Daejeon 34141, South KoreaKorea Res Inst Biosci & Biotechnol, Biotherapeut Translat Res Ctr, Div Biomed Sci, Daejeon 34141, South Korea
Kim, Seon-Kyu
论文数: 引用数:
h-index:
机构:
Min, Jeong-Ki
Han, Tae-Su
论文数: 0引用数: 0
h-index: 0
机构:
Korea Res Inst Biosci & Biotechnol, Biotherapeut Translat Res Ctr, Div Biomed Sci, Daejeon 34141, South KoreaKorea Res Inst Biosci & Biotechnol, Biotherapeut Translat Res Ctr, Div Biomed Sci, Daejeon 34141, South Korea
Han, Tae-Su
Kim, Jang-Seong
论文数: 0引用数: 0
h-index: 0
机构:
Korea Res Inst Biosci & Biotechnol, Biotherapeut Translat Res Ctr, Div Biomed Sci, Daejeon 34141, South Korea
Univ Sci & Technol, Dept Funct Genom, Daejeon 34141, South KoreaKorea Res Inst Biosci & Biotechnol, Biotherapeut Translat Res Ctr, Div Biomed Sci, Daejeon 34141, South Korea
机构:
Beibei Tradit Chinese Med Hosp, Dept Gen Surg, Chongqing, Peoples R ChinaBeibei Tradit Chinese Med Hosp, Dept Gen Surg, Chongqing, Peoples R China
Huang, Long
Dai, Gang
论文数: 0引用数: 0
h-index: 0
机构:
Fengdu Peoples Hosp, Dept Gen Surg, 214 Pingdu Ave, Chongqing 408200, Peoples R ChinaBeibei Tradit Chinese Med Hosp, Dept Gen Surg, Chongqing, Peoples R China
机构:
Soochow Univ, Sch Biol & Basic Med Sci, Suzhou 215213, Jiangsu, Peoples R China
Peking Univ China, Grad Sch, Japan Friendship Sch Clin Med, Beijing 100029, Peoples R China
Chinese Acad Med Sci & Peking Union Med Coll, Grad Sch, Beijing 100029, Peoples R ChinaSoochow Univ, Sch Biol & Basic Med Sci, Suzhou 215213, Jiangsu, Peoples R China
Zhao, Dong-Yan
Yin, Teng-Fei
论文数: 0引用数: 0
h-index: 0
机构:
Shandong Univ, Dept Gastroenterol, Qilu Hosp, Jinan 250012, Shandong, Peoples R ChinaSoochow Univ, Sch Biol & Basic Med Sci, Suzhou 215213, Jiangsu, Peoples R China
Yin, Teng-Fei
Sun, Xi-Zhen
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Jishuitan Hosp, Dept Gastroenterol, Beijing 100035, Peoples R ChinaSoochow Univ, Sch Biol & Basic Med Sci, Suzhou 215213, Jiangsu, Peoples R China
Sun, Xi-Zhen
Zhou, Yuan-Chen
论文数: 0引用数: 0
h-index: 0
机构:
China Japan Friendship Hosp, Dept Gastroenterol, Beijing 100029, Peoples R ChinaSoochow Univ, Sch Biol & Basic Med Sci, Suzhou 215213, Jiangsu, Peoples R China
Zhou, Yuan-Chen
Wang, Qian-Qian
论文数: 0引用数: 0
h-index: 0
机构:
China Japan Friendship Hosp, Dept Gastroenterol, Beijing 100029, Peoples R China
Peking Univ China, Grad Sch, Japan Friendship Sch Clin Med, Beijing 100029, Peoples R ChinaSoochow Univ, Sch Biol & Basic Med Sci, Suzhou 215213, Jiangsu, Peoples R China
Wang, Qian-Qian
Zhou, Ge-Yujia
论文数: 0引用数: 0
h-index: 0
机构:
China Japan Friendship Hosp, Dept Gastroenterol, Beijing 100029, Peoples R ChinaSoochow Univ, Sch Biol & Basic Med Sci, Suzhou 215213, Jiangsu, Peoples R China
Zhou, Ge-Yujia
Yao, Shu-Kun
论文数: 0引用数: 0
h-index: 0
机构:
China Japan Friendship Hosp, Dept Gastroenterol, Beijing 100029, Peoples R China
China Japan Friendship Hosp, Dept Gastroenterol, 2 Yinghua East Rd, Beijing 100029, Peoples R ChinaSoochow Univ, Sch Biol & Basic Med Sci, Suzhou 215213, Jiangsu, Peoples R China
机构:
School of Biology&Basic Medical Sciences,Soochow UniversitySchool of Biology&Basic Medical Sciences,Soochow University
Dong-Yan Zhao
Teng-Fei Yin
论文数: 0引用数: 0
h-index: 0
机构:
Department of Gastroenterology,Qilu Hospital of Shandong UniversitySchool of Biology&Basic Medical Sciences,Soochow University
Teng-Fei Yin
Xi-Zhen Sun
论文数: 0引用数: 0
h-index: 0
机构:
Department of Gastroenterology,Beijing Jishuitan HospitalSchool of Biology&Basic Medical Sciences,Soochow University
Xi-Zhen Sun
Yuan-Chen Zhou
论文数: 0引用数: 0
h-index: 0
机构:
Department of Gastroenterology,China-Japan Friendship Hospital
Graduate School,Peking University China-Japan Friendship School of Clinical MedicineSchool of Biology&Basic Medical Sciences,Soochow University
Yuan-Chen Zhou
Qian-Qian Wang
论文数: 0引用数: 0
h-index: 0
机构:
Department of Gastroenterology,China-Japan Friendship Hospital
Graduate School,Peking University China-Japan Friendship School of Clinical MedicineSchool of Biology&Basic Medical Sciences,Soochow University
Qian-Qian Wang
Ge-Yujia Zhou
论文数: 0引用数: 0
h-index: 0
机构:
Department of Gastroenterology,China-Japan Friendship Hospital
Graduate School,Chinese Academy of Medical Sciences and Peking Union Medical CollegeSchool of Biology&Basic Medical Sciences,Soochow University
Ge-Yujia Zhou
Shu-Kun Yao
论文数: 0引用数: 0
h-index: 0
机构:
Department of Gastroenterology,China-Japan Friendship HospitalSchool of Biology&Basic Medical Sciences,Soochow University