Direct, highly enantioselective pyrrolidine sulfonamide catalyzed Michael addition of aldehydes to nitrostyrenes

被引：361
|
作者：
Wang, W [1 ]
Wang, J [1 ]
Li, H [1 ]
机构：
[1] Univ New Mexico, Dept Chem, Albuquerque, NM 87131 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 09期
关键词：
aldehydes; asymmetric catalysis; Michael addition; nitroalkenes; organocatalysts;
D O I：
10.1002/anie.200461959
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Just can't get enough: The highly versatile pyrrolidine sulfonamide organocatalyst 1, which has been used in α-aminoxylation and Mannich-type reactions, also mediates diastereo- and enantioselective Michael addition reactions of aldehydes and ketones to nitroolefins (see scheme). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：1369 / 1371
页数：3
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