Current nutritional and pharmacological anti-aging interventions

被引:58
作者
Ros, Manuel [1 ]
Maria Carrascosa, Jose [2 ]
机构
[1] Univ Rey Juan Carlos, Fac Ciencias Salud, Madrid 28922, Spain
[2] UAM, Fac Ciencias, CSIC, Ctr Biol Mol Severo Ochoa, Madrid 28049, Spain
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2020年 / 1866卷 / 03期
关键词
Aging; Caloric restriction; Health span; Longevity; Anti-aging diets; Anti-aging treatments; EXTENDS LIFE-SPAN; TERM CALORIE RESTRICTION; REDUCED MEAL FREQUENCY; INDUCED WEIGHT-LOSS; DIETARY RESTRICTION; METHIONINE RESTRICTION; GLUCOSE-METABOLISM; RHESUS-MONKEYS; HEALTH SPAN; SACCHAROMYCES-CEREVISIAE;
D O I
10.1016/j.bbadis.2019.165612
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Aging is the main risk factor for chronic diseases and disablement in human societies with a great impact in social and health care expenditures. So far, aging and, eventually, death are unavoidable. Nevertheless, research efforts on aging-associated diseases with the aim not only to extend life span but also to increment health span in an attempt to delay, stop and even reverse the aging process have not stopped growing. Caloric restriction extends both health and life span in several short-lived experimental models and has brought to light the role of different molecular effectors involved in nutrient sensing pathways and longevity. This opens the possibility of modulating these molecular effectors also in humans to increase longevity and health span. The difficulty to implement caloric restricted diets in humans has led to the development of new bearable diets such as time-restricted feeding, intermittent fasting or diets with limited amounts of some nutrients and to the search of pharmacological agents, targeted to the effectors that mediate the extension of life and health span in response to these anti-aging diets. Pharmacological approaches that eliminate senescent cells or prevent primary causes of aging such as telomere attrition also emerge as potential anti-aging strategies. In the present article, we review these possible nutritional and pharmacological interventions designed to mitigate and/or delay the aging process and to increase health and life span.
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页数:10
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