A synthetic divalent cholera toxin glycocalix[4]arene ligand having higher affinity than natural GM1 oligosaccharide

被引：71
作者：
Arosio, D
Fontanella, M
Baldini, L
Mauri, L
Bernardi, A
Casnati, A
Sansone, F
Ungaro, R
机构：
[1] Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy
[2] CISI, Ctr Eccellenza, I-20133 Milan, Italy
[3] Univ Parma, Dipartimento Chim Organ & Ind, I-43100 Parma, Italy
[4] Univ Milan, Dipartimento Chim Biochim & Biotecnol Med, Segrate, MI, Italy
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 11期
关键词：
D O I：
10.1021/ja0444029
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A high-affinity ligand of cholera toxin, the divalent glycocalix[4]arene 1, was obtained by exploiting a combination of structure-based design of glycomimetic monovalent ligands and affinity enhancements by multivalent presentation through a calix[4]arene scaffold. It exhibits a slightly higher affinity for the toxin than its natural ligand, the GM1 oligosaccharide. Copyright © 2005 American Chemical Society.
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页码：3660 / 3661
页数：2
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