Intellective and stimuli-responsive drug delivery systems in eyes

被引：35

作者：

Lin, Xueqi ^{[1
]}

Wu, Xingdi ^{[1
]}

Chen, Xiang ^{[1
]}

Wang, Ben ^{[2
,3
]}

Xu, Wen ^{[1
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Eye Ctr, Hangzhou 310009, Zhejiang, Peoples R China

[2] Zhejiang Univ, Affiliated Hosp 2, China Natl Minist Educ, Sch Med,Canc Inst,Key Lab Canc Prevent & Interven, Hangzhou 310009, Zhejiang, Peoples R China

[3] Zhejiang Univ, Inst Translat Med, Hangzhou 310029, Zhejiang, Peoples R China

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2021年 / 602卷

关键词：

Ocular drug delivery; Stimuli-responsive systems; Controlled release; Nanoparticle as delivery vehicle; IN-SITU GEL; FORMING INJECTABLE IMPLANTS; EMBEDDED CONTACT-LENSES; POSTERIOR SEGMENT; CONTROLLED-RELEASE; CANCER-TREATMENT; GELLING SYSTEMS; CHOROIDAL NEOVASCULARIZATION; CONDUCTING POLYMERS; HYDROGEN-PEROXIDE;

D O I：

10.1016/j.ijpharm.2021.120591

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Stimuli-responsive drug delivery systems have attracted widespread attention in recent years since they can control drug release in a spatiotemporal manner and can achieve tunable drug release according to patient's physiological or pathological condition. In this review, we briefly introduce the drug delivery barriers and drug delivery systems in the anterior and posterior segment of eyes, and collect the recent advances in stimuliresponsive drug delivery systems in eyes for controlled drug release in response to exogenous stimuli (ultrasound, magnetic stimulus, electrical stimulus, and light) or endogenous stimuli (enzyme, active oxygen species, temperature, ions, and pH). In addition, the design and mechanisms of the stimuli-responsive drug delivery systems have been summarized in this review, and the advantages and limitations are also briefly discussed.

引用

页数：17

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