Intellective and stimuli-responsive drug delivery systems in eyes

被引：35
|
作者：
Lin, Xueqi [1 ]
Wu, Xingdi [1 ]
Chen, Xiang [1 ]
Wang, Ben [2 ,3 ]
Xu, Wen [1 ]
机构：
[1] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Eye Ctr, Hangzhou 310009, Zhejiang, Peoples R China
[2] Zhejiang Univ, Affiliated Hosp 2, China Natl Minist Educ, Sch Med,Canc Inst,Key Lab Canc Prevent & Interven, Hangzhou 310009, Zhejiang, Peoples R China
[3] Zhejiang Univ, Inst Translat Med, Hangzhou 310029, Zhejiang, Peoples R China
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2021年 / 602卷
关键词：
Ocular drug delivery; Stimuli-responsive systems; Controlled release; Nanoparticle as delivery vehicle; IN-SITU GEL; FORMING INJECTABLE IMPLANTS; EMBEDDED CONTACT-LENSES; POSTERIOR SEGMENT; CONTROLLED-RELEASE; CANCER-TREATMENT; GELLING SYSTEMS; CHOROIDAL NEOVASCULARIZATION; CONDUCTING POLYMERS; HYDROGEN-PEROXIDE;
D O I：
10.1016/j.ijpharm.2021.120591
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Stimuli-responsive drug delivery systems have attracted widespread attention in recent years since they can control drug release in a spatiotemporal manner and can achieve tunable drug release according to patient's physiological or pathological condition. In this review, we briefly introduce the drug delivery barriers and drug delivery systems in the anterior and posterior segment of eyes, and collect the recent advances in stimuliresponsive drug delivery systems in eyes for controlled drug release in response to exogenous stimuli (ultrasound, magnetic stimulus, electrical stimulus, and light) or endogenous stimuli (enzyme, active oxygen species, temperature, ions, and pH). In addition, the design and mechanisms of the stimuli-responsive drug delivery systems have been summarized in this review, and the advantages and limitations are also briefly discussed.
引用
收藏
页数：17
相关论文
共 50 条
  • [1] Stimuli-responsive drug delivery systems
    Yang, Jerry
    ADVANCED DRUG DELIVERY REVIEWS, 2012, 64 (11) : 965 - 966
  • [2] Stimuli-responsive systems for tuneable ocular drug delivery
    Rupenthal, I. D.
    Yasin, N.
    Bisht, R.
    Chen, Y. S.
    Jin, J.
    Jaiswal, J.
    Svirskis, D.
    ACTA OPHTHALMOLOGICA, 2016, 94
  • [3] Stimuli-responsive nanocarriers for drug delivery
    Simona Mura
    Julien Nicolas
    Patrick Couvreur
    Nature Materials, 2013, 12 : 991 - 1003
  • [4] Stimuli-responsive dendrimers in drug delivery
    Wang, Hui
    Huang, Quan
    Chang, Hong
    Xiao, Jianru
    Cheng, Yiyun
    BIOMATERIALS SCIENCE, 2016, 4 (03) : 375 - 390
  • [5] Stimuli-responsive nanocarriers for drug delivery
    Mura, Simona
    Nicolas, Julien
    Couvreur, Patrick
    NATURE MATERIALS, 2013, 12 (11) : 991 - 1003
  • [6] Stimuli-responsive nanocarriers for drug delivery
    Institut Galien Paris-Sud, Université Paris-Sud, Faculté de Pharmacie, 5 rue Jean-Baptiste Clément, F-92296 Châtenay-Malabry cedex, France
    Nat. Mater., 2013, 11 (991-1003):
  • [7] Stimuli-responsive liposomes for drug delivery
    Lee, Y.
    Thompson, D. H.
    WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 2017, 9 (05)
  • [8] Stimuli-responsive nanoscale drug delivery systems for cancer therapy
    Li, Li
    Yang, Wu-Wei
    Xu, Dong-Gang
    JOURNAL OF DRUG TARGETING, 2019, 27 (04) : 423 - 433
  • [9] Classification of stimuli-responsive polymers as anticancer drug delivery systems
    Taghizadeh, Bita
    Taranejoo, Shahrouz
    Monemian, Seyed Ali
    Moghaddam, Zoha Salehi
    Daliri, Karim
    Derakhshankhah, Hossein
    Derakhshani, Zaynab
    DRUG DELIVERY, 2015, 22 (02) : 145 - 155
  • [10] Advances in Stimuli-Responsive Chitosan Hydrogels for Drug Delivery Systems
    Xia, Yuhan
    Ma, Zhiyuan
    Wu, Xuechen
    Wei, Huidan
    Zhang, Han
    Li, Guang
    Qian, Yuqi
    Shahriari-Khalaji, Mina
    Hou, Kai
    Cao, Ran
    Zhu, Meifang
    MACROMOLECULAR BIOSCIENCE, 2024, 24 (05)
12345