Methylcellulose - a versatile printing material that enables biofabrication of tissue equivalents with high shape fidelity

被引：82

作者：

Ahlfeld, T. ^{[1
,2
]}

Guduric, V. ^{[1
,2
]}

Duin, S. ^{[1
,2
]}

Akkineni, A. R. ^{[1
,2
]}

Schuetz, K. ^{[1
,2
]}

Kilian, D. ^{[1
,2
]}

Emmermacher, J. ^{[1
,2
]}

Cubo-Mateo, N. ^{[1
,2
]}

Dani, S. ^{[1
,2
]}

Witzleben, M. v. ^{[1
,2
]}

Spangenberg, J. ^{[1
,2
]}

Abdelgaber, R. ^{[1
,2
]}

Richter, R. F. ^{[1
,2
]}

Lode, A. ^{[1
,2
]}

Gelinsky, M. ^{[1
,2
]}

机构：

[1] Univ Hosp Carl Gustav Carus, Ctr Translat Bone Joint & Soft Tissue Res, D-01307 Dresden, Germany

[2] Tech Univ Dresden, Fac Med, D-01307 Dresden, Germany

来源：

BIOMATERIALS SCIENCE | 2020年 / 8卷 / 08期

关键词：

PHYSICAL-PROPERTIES; THERMAL GELATION; HYALURONIC-ACID; HYDROGELS; METHYL;

D O I：

10.1039/d0bm00027b

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

With the aid of biofabrication, cells can be spatially arranged in three dimensions, which offers the opportunity to guide tissue maturation in a better way compared to traditional tissue engineering approaches. A prominent technique allowing biofabrication of tissue equivalents is extrusion-based 3D (bio)printing, also called 3D (bio)plotting or robocasting, which comprises cells embedded in the biomaterial (bioink) during the fabrication process. First bioprinting studies introduced bioinks allowing either good cell viability or good shape fidelity. Concepts enabling printing of cell-laden constructs with high shape fidelity were developed only rarely. Recent studies showed the great potential of the polysaccharide methylcellulose (mc) as supportive biomaterial that can be utilized in various ways to enable biofabrication and especially extrusion-based bioprinting of bioinks. This minireview highlights the multiple applications of mc for biofabrication: it was successfully used as sacrificial ink to enable 3D shaping of cell sheets or biomaterial inks as well as as internal stabilizing component of various bioinks. Moreover, a brief overview about first bioprinted functional tissue equivalents is given, which have been fabricated by using mc. Based on these studies, future research should consider mc as an auxiliary material for bioinks and biofabricated constructs with high shape fidelity.

引用

页码：2102 / 2110

页数：9

共 54 条

[1] Development of a clay based bioink for 3D cell printing for skeletal application [J].