Impact of rpoB Mutations on Reduced Vancomycin Susceptibility in Staphylococcus aureus

被引：97

作者：

Watanabe, Yukiko ^{[2
]}

Cui, Longzhu ^{[1
,2
]}

Katayama, Yuki ^{[1
]}

Kozue, Kishii ^{[2
]}

Hiramatsu, Keiichi ^{[1
,2
]}

机构：

[1] Juntendo Univ, Fac Med, Dept Bacteriol, Bunkyo Ku, Tokyo 1138421, Japan

[2] Juntendo Univ, Dept Infect Control Sci, Grad Sch Med, Bunkyo Ku, Tokyo 1138421, Japan

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2011年 / 49卷 / 07期

关键词：

RESISTANCE; INTERMEDIATE; STRAINS; DISSEMINATION; DAPTOMYCIN; HOSPITALS;

D O I：

10.1128/JCM.02144-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Of 38 vancomycin-intermediate Staphylococcus aureus (VISA) clinical strains, 27 (71%) possessed a mutation(s) in rpoB encoding the beta-subunit of RNA polymerase. Furthermore, 95.6% of the rifampin-resistant mutants obtained from 9 methicillin-resistant S. aureus (MRSA) clinical isolates showed decreased vancomycin susceptibilities. These data indicate the involvement of an rpoB mutation in VISA phenotype expression.

引用

页码：2680 / 2684

页数：5

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