Role of adiponectin on antioxidant profile: evaluation during healthy and hypertensive disorders of pregnancy

被引：10

作者：

Eleuterio, Nibia Mariana ^{[1
]}

Palei, Ana C. T. ^{[2
]}

Rangel Machado, Jackeline S. ^{[3
]}

Tanus-Santos, Jose E. ^{[4
]}

Cavalli, Ricardo C. ^{[3
]}

Sandrim, Valeria C. ^{[1
]}

机构：

[1] State Univ Sao Paulo UNESP, Inst Biosci, Dept Pharmacol, Botucatu, SP, Brazil

[2] Univ Estadual Campinas, Dept Pharmacol, Fac Med Sci, Campinas, SP, Brazil

[3] Univ Sao Paulo, Dept Gynecol & Obstet, Fac Med Ribeirao Preto, Ribeirao Preto, SP, Brazil

[4] Univ Sao Paulo, Dept Pharmacol, Fac Med Ribeirao Preto, Ribeirao Preto, SP, Brazil

来源：

BLOOD PRESSURE | 2016年 / 25卷 / 04期

基金：

巴西圣保罗研究基金会;

关键词：

Adipokines; gestational hypertension; oxidative stress; pre-eclampsia; pregnancy; SERUM ADIPONECTIN; OXIDATIVE STRESS; CIRCULATING LEVELS; DIABETES-MELLITUS; PREECLAMPSIA; ADIPOKINES; LEPTIN; RISK;

D O I：

10.3109/08037051.2015.1134550

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The study of adipokines and oxidative stress has aided in understanding pre-eclampsia physiopathology. Therefore, our group aimed to evaluate the correlation between the adipokines (adiponectin and leptin) and the oxidative stress marker malondialdehyde-thiobarbituric acid reactive substances (MDA-TBARS) and antioxidant activity of plasma [ferric reducing ability of plasma (FRAP)] in healthy pregnant women and patients with gestational hypertension and pre-eclampsia. We found a significant negative correlation between MDA-TBARS and adiponectin (r=-0.40, p=0.0042), suggesting a relationship between antioxidant levels and this adipokine in healthy pregnancies which is altered in patients with gestational hypertension or pre-eclampsia.

引用

页码：241 / 243

页数：3

共 20 条

[1] The effects of oxidative stress on female reproduction: a review [J].

Agarwal, Ashok ;

Aponte-Mellado, Anamar ;

Premkumar, Beena J. ;

Shaman, Amani ;

Gupta, Sajal .

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 2012, 10

[2] Low fat adiponectin expression is associated with oxidative stress in nondiabetic humans with chronic kidney disease - impact on plasma adiponectin concentration [J].

Barazzoni, Rocco ;

Bernardi, Annamaria ;

Biasia, Franco ;

Semolic, Annamaria ;

Bosutti, Alessandra ;

Mucci, MariaPia ;

Dore, Franca ;

Zanetti, Michela ;

Guarnieri, Gianfranco .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2007, 293 (01) :R47-R54

[3] The ferric reducing ability of plasma (FRAP) as a measure of ''antioxidant power'': The FRAP assay [J].

Benzie, IFF ;

Strain, JJ .

ANALYTICAL BIOCHEMISTRY, 1996, 239 (01) :70-76

[4]

Buege J A, 1978, Methods Enzymol, V52, P302

[5] Oxidative stress [J].

Burton, Graham J. ;

Jauniaux, Eric .

BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY, 2011, 25 (03) :287-299

[6] Plasma adiponectin concentration in early pregnancy and subsequent risk of hypertensive disorders [J].

D'Anna, R ;

Baviera, G ;

Corrado, F ;

Giordano, D ;

Di Benedetto, A ;

Jasonni, VM .

OBSTETRICS AND GYNECOLOGY, 2005, 106 (02) :340-344

[7] Serum adiponectin and leptin in relation to risk for preeclampsia: results from a large case-control study [J].

Dalamaga, Maria ;

Srinivas, Sindhu K. ;

Elovitz, Michal A. ;

Chamberland, John ;

Mantzoros, Christos S. .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2011, 60 (11) :1539-1544

[8] Correlations between circulating levels of adipokines and anti-angiogenic factors in women with BMI <30 and a late-onset preeclampsia [J].

Eleuterio, Nibia Mariana ;

Palei, Ana C. T. ;

Rangel Machado, Jackeline S. ;

Tanus-Santos, Jose E. ;

Cavalli, Ricardo C. ;

Sandrim, Valeria C. .

HYPERTENSION IN PREGNANCY, 2014, 33 (01) :72-80

[9] A longitudinal study of serum adiponectin during normal pregnancy [J].

Fuglsang, J ;

Skjærbæk, C ;

Frystyk, J ;

Flyvbjerg, A ;

Ovesen, P .

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2006, 113 (01) :110-113

[10] Protective vascular and myocardial effects of adiponectin [J].

Goldstein, Barry J. ;

Scalia, Rosario G. ;

Ma, Xin L. .

NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE, 2009, 6 (01) :27-35

← 1 2 →