Genetic findings in schizophrenia patients related to alterations in the intracellular Ca-homeostasis

被引：19

作者：

Giegling, Ina ^{[1
]}

Genius, Just ^{[1
]}

Benninghoff, Jens ^{[1
]}

Rujescu, Dan ^{[1
]}

机构：

[1] Univ Munich, Dept Psychiat, Div Mol & Clin Neurobiol, D-80336 Munich, Germany

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2010年 / 34卷 / 08期

关键词：

Calcium; Genetics; GWA; NMDA; Schizophrenia; SNP; GENOME-WIDE ASSOCIATION; AMINO-ACID OXIDASE; SYNTHASE NOS1 GENE; BIPOLAR DISORDER; NEUREGULIN; RECEPTOR HYPOFUNCTION; ALLELIC ASSOCIATION; SUSCEPTIBILITY GENE; COMMON VARIANTS; WORKING-MEMORY;

D O I：

10.1016/j.pnpbp.2010.06.018

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

There is a relatively high genetic heritability of schizophrenia as shown by family, twin and adoption studies. A large number of hypotheses on the causes of schizophrenia occurred overtime. In this review we focus on genetic findings related to potential alterations of intracellular Ca-homeostasis in association with schizophrenia. First, we provide evidence for the NMDA/glutamatergic theory of schizophrenia including calcium processes. We mainly focus on genes including: DAD (D-amino acid oxidase), DADA (D-amino acid oxidase activator), DTNBP1 (Dysbindin 1, dystrobrevin-binding protein 1), NRG1 (Neuregulin 1), ERBB4 (v-erb-a erythroblastic leukemia viral oncogene homolog 4, avian), NOS1 (nitric oxide synthase 1, neuronal) and NRGN (Neurogranin). Furthermore, a gene coding for a calcium channel subunit (CACNA1C: calcium channel, voltage-dependent, L type, alpha 1C subunit) is discussed in the light of schizophrenia whereas genetic findings related to alterations in the intracellular Ca-homeostasis associated specifically with dopaminergic and serotonergic neurotransmission in schizophrenia are not herein closer reviewed. Taken together there is converging evidence for the contribution of genes potentially related to alterations in intracellular Ca-homeostasis to the risk of schizophrenia. Replications and functional studies will hopefully provide further insight into these genetic variants and the underlying processes. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：1375 / 1380

页数：6

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