Synthesis and antimicrobial activity of new 3-amino suphonyl[3′-chloro-4′-(substituted phenyl)-2′-oxo azetidine]indole

A series of new 3-amino sulphonyl[3 '-chloro-4 '-(substituted phenyl)-2 '-oxo azetidine]indole derivatives (5a-j) have been prepared from the respective 3-(sub)stituted benzylidene hydrazine) sulphonyl indoles (4a-j) by treating with chloroacetyl chloride in presence of ethanol. The required substituted benzylidene hydrazino sulphonyl indoles (4a-j) were obtained from hydrazino sulphonyl indole (3) by condensing with appropriate aromatic aldehydes. Chloro-sulphonyl indole (2) when treated with hydrazine yielded the respective hydrazides, 3-Aminosulphonyl [3 '-chloro-4 '-(4-nitro phenyl)-2 '-oxo azetidine]indole showed moderate to good antimicrobial activity.