Caenorhabditis elegans as an Emerging Model for Virus-Host Interactions

被引：0
作者：
Gammon, Don B. [1 ]
机构：
[1] Univ Texas Southwestern Med Ctr Dallas, Dept Microbiol, Dallas, TX 75390 USA
来源：
JOURNAL OF VIROLOGY | 2017年 / 91卷 / 23期
关键词：
Caenorhabditis elegans; Flock House virus; innate immunity; Orsay virus; RNA interference; virus-host interactions; vesicular stomatitis virus; ANTIVIRAL RNA INTERFERENCE; DOUBLE-STRANDED-RNA; ORSAY VIRUS; INNATE IMMUNITY; BINDING-PROTEIN; C; ELEGANS; INFECTION; REPLICATION; HELICASE; RDE-4;
D O I：
10.1128/JVI.00509-17
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Since 1999, Caenorhabditis elegans has been extensively used to study microbe-host interactions due to its simple culture, genetic tractability, and susceptibility to numerous bacterial and fungal pathogens. In contrast, virus studies have been hampered by a lack of convenient virus infection models in nematodes. The recent discovery of a natural viral pathogen of C. elegans and development of diverse artificial infection models are providing new opportunities to explore virus-host interplay in this powerful model organism.
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页数：7
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