Observing the repulsion layers on blood-compatible polymer-grafted interfaces by frequency modulation atomic force microscopy

被引：6
作者：
Murakami, Daiki [1 ,2 ]
Nishimura, Shin-nosuke [1 ]
Tanaka, Yukiko [1 ]
Tanaka, Masaru [1 ,2 ]
机构：
[1] Kyushu Univ, Inst Mat Chem & Engn, Nishi Ku, CE41,744 Motooka, Fukuoka 8190395, Japan
[2] Kyushu Univ, Grad Sch Engn, Nishi Ku, CE41,744 Motooka, Fukuoka 8190395, Japan
来源：
BIOMATERIALS ADVANCES | 2022年 / 133卷
关键词：
Frequency modulation atomic force microscopy; Blood-compatible polymer; Hydration; WATER-MOLECULES; ADSORPTION; BIOMATERIAL; SURFACES; BRUSHES; RESIST;
D O I：
10.1016/j.msec.2021.112596
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Blood-compatible materials that do not promote reactions in contact with human blood are required to support emerging medical technologies. The interfaces of poly(2-methoxyethyl acrylate) (PMEA), a blood-compatible polymer, and its analogues were investigated by frequency modulation atomic force microscopy (FM-AFM). The grafted polymers exhibited phase separation into polymer-rich and water-rich domains. Thin repulsive layers of hydrated polymer chains were observed in the water-rich domains of the blood-compatible polymers; on the other hand, such layers were not observed for the non-blood-compatible polymers. We report for the first time that FM-AFM enables characteristic repulsive layers composed of hydrated polymer chains in water-rich domains to be observed, which is a significant design factor for blood-compatible polymers.
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页数：4
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