Atypical chemokine receptors

被引：108

作者：

Ulvmar, Maria Helena ^{[1
]}

Hub, Elin ^{[1
]}

Rot, Antal ^{[1
]}

机构：

[1] Univ Birmingham, MRC, Ctr Immune Regulat, Sch Infect & Immun, Birmingham B15 2TT, W Midlands, England

来源：

EXPERIMENTAL CELL RESEARCH | 2011年 / 317卷 / 05期

关键词：

ACR; DARC; D6; CXCR7; CCRL1; CCRL2; Interceptor; DUFFY ANTIGEN RECEPTOR; RED-BLOOD-CELLS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; MESSENGER-RNA EXPRESSION; HIGH ENDOTHELIAL VENULES; HIV-AIDS SUSCEPTIBILITY; IN-VIVO; PLASMODIUM-VIVAX; L-CCR; T-LYMPHOCYTES;

D O I：

10.1016/j.yexcr.2011.01.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Atypical chemokine receptors (ACRs) are cell surface receptors with seven transmembrane domains structurally homologous to chemokine G-protein coupled receptors (GPCRs). However, upon ligation by cognate chemokines, ACRs fail to induce classical signaling and downstream cellular responses characteristic for GPCRs. Despite this, by affecting chemokine availability and function, ACRs impact on a multitude of pathophysiological events and have emerged as important molecular players in health and disease. This review discusses individual characteristics of the currently known ACRs, highlights their similarities and differences and attempts to establish their group identity. It summarizes the progress made in mapping ACR expression, understanding their diverse in vitro and in vivo functions of ACRs and uncovering their contributions to disease pathogeneses. (C) 2011 Elsevier Inc. All rights reserved.

引用

收藏

页码：556 / 568

页数：13

相关论文

共 170 条

[1] Overexpression of the duffy antigen receptor for chemokines (DARC) by NSCLC tumor cells results in increased tumor necrosis [J].

Addison, CL ;

Belperio, JA ;

Burdick, MD ;

Strieter, RM .

BMC CANCER, 2004, 4 (1)

[2] Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression [J].

Ariel, Amiram ;

Fredman, Gabrielle ;

Sun, Yee-Ping ;

Kantarci, Alpdogan ;

Van Dyke, Thomas E. ;

D Luster, Andrew ;

Serhan, Charles N. .

NATURE IMMUNOLOGY, 2006, 7 (11) :1209-1216

[3] The CCR7 ligand ELC (CCL19) is transcytosed in high endothelial venules and mediates T cell recruitment [J].

Baekkevold, ES ;

Yamanaka, T ;

Palframan, RT ;

Carlsen, HS ;

Reinholt, FP ;

von Andrian, UH ;

Brandtzaeg, P ;

Haraldsen, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (09) :1105-1111

[4] The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes [J].

Balabanian, K ;

Lagane, B ;

Infantino, S ;

Chow, KYC ;

Harriague, J ;

Moepps, B ;

Arenzana-Seisdedos, F ;

Thelen, M ;

Bachelerie, F .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (42) :35760-35766

[5] The C5a Receptor (C5aR) C5L2 Is a Modulator of C5aR-mediated Signal Transduction [J].

Bamberg, Claire E. ;

Mackay, Charles R. ;

Lee, Hyun ;

Zahra, David ;

Jackson, Jenny ;

Lim, Yun Si ;

Whitfeld, Peter L. ;

Craig, Stewart ;

Corsini, Erin ;

Lu, Bao ;

Gerard, Craig ;

Gerard, Norma P. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (10) :7633-7644

[6] Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression [J].

Bandyopadhyay, Sucharita ;

Zhan, Rui ;

Chaudhuri, Asok ;

Watabe, Misako ;

Pai, Sudha K. ;

Hirota, Shigeru ;

Hosobe, Sadahiro ;

Tsukada, Taisei ;

Miura, Kunio ;

Takano, Yukio ;

Saito, Ken ;

Pauza, Mary E. ;

Hayashi, Sunao ;

Wang, Ying ;

Mohinta, Sonia ;

Mashimo, Tomoyuki ;

Iiizumi, Megumi ;

Furuta, Eiji ;

Watabe, Kounosuke .

NATURE MEDICINE, 2006, 12 (08) :933-938

[7] CXCR7 Protein Is Not Expressed on Human or Mouse Leukocytes [J].

Berahovich, Robert D. ;

Zabel, Brian A. ;

Penfold, Mark E. T. ;

Lewen, Susanna ;

Wang, Yu ;

Miao, Zhenhua ;

Gan, Lin ;

Pereda, Jaime ;

Dias, Jessica ;

Slukvin, Igor I. ;

McGrath, Kathleen E. ;

Jaen, Juan C. ;

Schall, Thomas J. .

JOURNAL OF IMMUNOLOGY, 2010, 185 (09) :5130-5139

[8] The chemokine scavenging receptor D6 limits acute toxic liver injury in vivo [J].

Berres, Marie-Luise ;

Trautwein, Christian ;

Zaldivar, Mirko Moreno ;

Schmitz, Petra ;

Pauels, Katrin ;

Lira, Sergio A. ;

Tacke, Frank ;

Wasmuth, Hermann E. .

BIOLOGICAL CHEMISTRY, 2009, 390 (10) :1039-1045

[9] Expression of L-CCR in HEK 293 cells reveals functional responses to CCL2, CCL5, CCL7, and CCL8 [J].

Biber, K ;

Zuurman, MW ;

Homan, H ;

Boddeke, HWGM .

JOURNAL OF LEUKOCYTE BIOLOGY, 2003, 74 (02) :243-251

[10] Purification and biochemical characterization of the D6 chemokine receptor [J].

Blackburn, PE ;

Simpson, CV ;

Nibbs, RJB ;

O'Hara, M ;

Booth, R ;

Poulos, J ;

Isaacs, NW ;

Graham, GJ .

BIOCHEMICAL JOURNAL, 2004, 379 :263-272

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