Fabrication of injectable bone substitute loading porous simvastatin-loaded poly(lactic-co-glycolic acid) microspheres

被引：1

作者：

Nam Minh-Phuong Tran ^{[1
]}

Nhi Thao-Ngoc Dang ^{[1
]}

Nghi Thi-Phuong Nguyen ^{[1
]}

Long Vuong-Hoang Nguyen ^{[1
]}

Tran Ngoc Quyen ^{[2
,3
]}

Tran, Phong A. ^{[4
]}

Lee, Byong-Taek ^{[5
]}

Nguyen Thi Hiep ^{[1
]}

机构：

[1] Vietnam Natl Univ Ho Chi Minh City VNU HCM, Int Univ, Dept Biomed Engn, Tissue Engn & Regenerat Med Lab, Ho Chi Minh City, Vietnam

[2] Vietnam Acad Sci & Technol, Inst Appl Mat Sci, Ho Chi Minh City, Vietnam

[3] Grad Univ Sci & Technol Viet Nam, Vietnam Acad Sci & Technol, Ho Chi Minh City, Vietnam

[4] Queensland Univ Technol, Brisbane, Qld, Australia

[5] Soonchunhyang Univ, Coll Med, Dept Biomed Engn & Mat, Cheonan, South Korea

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2020年 / 69卷 / 06期

关键词：

Biphasic calcium phosphate; drug delivery system; injectable bone substitute; poly(lactic-co-glycolic acid) microspheres; simvastatin; PLGA MICROSPHERES; IN-VITRO; CALCIUM CITRATE; OPERATIVE TIME; CITRIC-ACID; SCAFFOLD; VIVO; BIOMATERIALS; OSTEOGENESIS; COMPOSITES;

D O I：

10.1080/00914037.2019.1566726

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

An injectable bone substitute (IBS) with well-controlled release mechanism of simvastatin (SIM) was fabricated from SIM loaded-porous poly(lactic-co-glycolic acid) microspheres (PLGA MSs), biphasic calcium phosphates (BCP) and CaCO3 nano powder as the solid phase and gelatin, citric acid and hydroxypropyl methylcellulose as the liquid phase. The ratios of PLGA MSs and BCP were varied to obtain IBS with optimal mechanical properties, biocompatibility and bioactivity. In vitro test with MG-63 pre-osteoblast cells showed that IBS with higher amount of PLGA MSs yield better cell adhesion and proliferation. In vivo study on rabbit femoral defect also suggested that the IBS promoted osteogenesis.

引用

页码：351 / 362

页数：12

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