Gene editing in T cell therapy

被引：13

作者：

Zhang, Yongping ^{[1
,2
]}

Mu, Wei ^{[1
,3
]}

Wang, Haoyi ^{[1
,3
]}

机构：

[1] Chinese Acad Sci, Inst Zool, State Key Lab Stem Cell & Reprod Biol, Beijing 100190, Peoples R China

[2] Peking Univ, Dept Hematol, Aerosp Ctr Hosp, Aerosp Clin Med Coll, Beijing 100049, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

JOURNAL OF GENETICS AND GENOMICS | 2017年 / 44卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Gene editing; CRISPR-Cas9; T cells; CHIMERIC-ANTIGEN-RECEPTOR; ZINC-FINGER-NUCLEASES; TUMOR-INFILTRATING LYMPHOCYTES; RNA-GUIDED ENDONUCLEASE; OFF-TARGET CLEAVAGE; HIV-1 PROVIRAL DNA; METASTATIC MELANOMA; IN-VIVO; CANCER-IMMUNOTHERAPY; COMBINATION IMMUNOTHERAPY;

D O I：

10.1016/j.jgg.2017.09.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The adoptive transfer of engineered T cells for the treatment of cancer, autoimmunity, and infectious disease is a rapidly growing field that has shown great promise. Gene editing holds tremendous potential for further improvements of T cell therapy. Here we review the applications of gene editing in various T cell therapies, focusing on antiviral strategies and cancer immunotherapies, and discuss the challenges and future prospects. Copyright (C) 2017, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. All rights reserved.

引用

页码：415 / 422

页数：8

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