Iridium-Catalyzed Asymmetric Intramolecular Allylic Amidation: Enantioselective Synthesis of Chiral Tetrahydroisoquinolines and Saturated Nitrogen Heterocycles

被引：59

作者：

Teichert, Johannes F. ^{[1
]}

Fananas-Mastral, Martin ^{[1
]}

Feringa, Ben L. ^{[1
]}

机构：

[1] Univ Groningen, Stratingh Inst Chem, NL-9747 AG Groningen, Netherlands

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 03期

关键词：

allylic compounds; asymmetric catalysis; iridium; nitrogen heterocycles; phosphoramidites; ANTITUMOR ANTIBIOTICS; AMINATION; PHOSPHORAMIDITE; SUBSTITUTIONS; ALKYLATION; ALKALOIDS; ISOQUINOLINES; METATHESIS; COMPLEXES; ALCOHOLS;

D O I：

10.1002/anie.201006039

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

For the first time iridium catalysis has been used for the synthesis of chiral tetrahydroisoquinolines with excellent yields and high enantioselectivities (see scheme; cod=1,5-cyclooctadiene, DBU=1,8- diazabicyclo[5.4.0]undec-7-ene). These products are important chiral building blocks for the synthesis of biologically active compounds, in particular alkaloids. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：688 / 691

页数：4