共 50 条
Ectopic fat deposition in populations of black African ancestry: A systematic review and meta-analysis
被引:9
作者:
Reed, Reuben M.
[1
]
Nevitt, Sarah J.
[2
]
Kemp, Graham J.
[3
]
Cuthbertson, Daniel J.
[4
]
Whyte, Martin B.
[5
]
Goff, Louise M.
[1
]
机构:
[1] Kings Coll London, Fac Life Sci & Med, Dept Nutr Sci, London, England
[2] Univ Liverpool, Dept Hlth Data Sci, Inst Populat Hlth, Liverpool, Merseyside, England
[3] Univ Liverpool, Dept Musculoskeletal & Ageing Sci, Inst Life Course & Med Sci, Liverpool Magnet Resonance Imaging Ctr LiMRIC, Liverpool, Merseyside, England
[4] Univ Liverpool, Dept Cardiovasc & Metab Med, Inst Life Course Sci, Liverpool, Merseyside, England
[5] Univ Surrey, Fac Hlth & Med Sci, Guildford, Surrey, England
关键词:
Black African ancestry;
Ectopic fat;
Intrahepatic lipid;
Intramyocellular lipid;
Intrapancreatic lipid;
Type;
2;
diabetes;
VISCERAL ADIPOSE-TISSUE;
BETA-CELL FUNCTION;
INSULIN-RESISTANCE;
ETHNIC-DIFFERENCES;
LIVER-DISEASE;
PANCREATIC FAT;
RACIAL-DIFFERENCES;
HEPATIC STEATOSIS;
EUROPEAN-AMERICAN;
UNITED-STATES;
D O I:
10.1007/s00592-021-01797-5
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Aims In populations of black African ancestry (BA), a paradox exists whereby lower visceral adipose tissue is found despite their high risk for type 2 diabetes (T2D). This systematic review investigates ethnic differences in other ectopic fat depots (intrahepatic lipid: IHL; intramyocellular lipid: IMCL and intrapancreatic lipid; IPL) to help contextualise their potential contribution to T2D risk. Methods A systematic literature search was performed in December 2020 to identify studies reporting at least one ectopic fat comparison between BA and one/more other ethnicity. For IHL, a meta-analysis was carried out with studies considered comparable based on the method of measurement. Results Twenty-eight studies were included (IHL: n = 20; IMCL: n = 8; IPL: n = 4). Meta-analysis of 11 studies investigating IHL revealed that it was lower in BA populations vs pooled ethnic comparators (MD -1.35%, 95% CI -1.55 to -1.16, I-2 = 85%, P < 0.00001), white European ancestry (MD -0.94%, 95% CI -1.17 to -0.70, I-2 = 79%, P < 0.00001), Hispanic ancestry (MD -2.06%, 95% CI -2.49 to -1.63, I-2 = 81%, P < 0.00001) and South Asian ancestry comparators (MD -1.92%, 95% CI -3.26 to -0.57, I-2 = 78%, P = 0.005). However, heterogeneity was high in all analyses. Most studies found no significant differences in IMCL between BA and WE. Few studies investigated IPL, however, indicated that IPL is lower in BA compared to WE and HIS. Conclusion The discordance between ectopic fat and greater risk for T2D in BA populations raises questions around its contribution to T2D pathophysiology in BA.
引用
收藏
页码:171 / 187
页数:17
相关论文
共 50 条