Mitochondria in health and disease

被引：43

作者：

Chakrabarty, Sanjiban ^{[1
]}

Kabekkodu, Shama Prasada ^{[1
]}

Singh, Rana P. ^{[2
]}

Thangaraj, K. ^{[3
]}

Singh, Keshav K. ^{[4
,5
,6
,7
]}

Satyamoorthy, Kapaettu ^{[1
]}

机构：

[1] Manipal Acad Higher Educ, Sch Life Sci, Dept Cell & Mol Biol, Manipal 576104, Karnataka, India

[2] Jawaharlal Nehru Univ, Sch Life Sci, New Delhi 110067, India

[3] CSIR, Ctr Cellular & Mol Biol, Uppal Rd, Hyderabad 500007, India

[4] Univ Alabama Birmingham, Dept Genet, Birmingham, AL USA

[5] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA

[6] Univ Alabama Birmingham, Dept Environm Hlth, Birmingham, AL USA

[7] Birmingham Vet Affairs Med Ctr, Birmingham, AL USA

来源：

MITOCHONDRION | 2018年 / 43卷

关键词：

Mitochondrial disease; Mitochondrial biomarkers; Mitochondrial genetics; miRNAs and mitochondria; Signaling and metabolism; Stem cells and mitochondria; OXIDATIVE-PHOSPHORYLATION; ANTICANCER AGENT; DNA VARIATIONS; CANCER-CELLS; MUTATION; SILIBININ;

D O I：

10.1016/j.mito.2018.06.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mitochondrial biology has become an area of intense research owing to the unique physiology of the organelle and its role in several types of cancers and other disorders. It has been found that mitochondria-encoded proteins, mitochondrial DNA and even RNA influence the functioning of the cell in more ways than were previously imagined. This may contribute to disease phenotypes which require detailed investigation and communication to the community health care providers. Additionally, this provides several novel avenues in drug designing against various cancers, neurodegenerative diseases and other metabolic disorders. The sixth annual conference of the Society for Mitochondrial Research and Medicine-India (SMRM) titled, 'Mitochondria in Health and Disease' was organized by Rana P. Singh at the School of Life Sciences, Jawaharlal Nehru University in New Delhi, India from 10th to 11th February 2017. The underlying objective of the conference was to provide a platform to discuss the recent advances in basic and translational research in mitochondrial biology and diseases. The conference aimed to translate academic research into clinical practice by providing a forum for basic researchers and clinicians to share their knowledge and build collaborations towards development of advanced therapeutic in mitochondrial diseases. To facilitate the knowledge-sharing, six major themes for the scientific sessions were (1) understanding of mitochondrial biology in disease progression, (2) advances in basic and translational mitochondrial research, (3) mitochondria in evolution and development, (4) targeting mitochondria for cancer prevention and treatment, (5) mitochondria in metabolic and neurological disorders and (6) mitochondria in stem cell and regeneration biology. This report summarizes the major outcomes of the discussions at the conference.

引用

页码：25 / 29

页数：5

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