An efficient and recyclable L-proline triflate ionic liquid catalyst for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones via the multi-component Biginelli reaction

被引：9

作者：

Khan Manh Hua ^{[1
]}

Phuong Hoang Tran ^{[1
]}

Thach Ngoc Le ^{[1
]}

机构：

[1] Vietnam Natl Univ, Univ Sci, Fac Chem, Dept Organ Chem, Ho Chi Minh City 700000, Vietnam

来源：

ARKIVOC | 2019年

关键词：

Biginelli reaction; ultrasonic irradiation; microwave irradiation; L-proline triflate; solvent-free conditions; ASSISTED SYNTHESIS; NANOPARTICLES; ULTRASOUND; GREEN;

D O I：

10.24820/ark.5550190.p011.096

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple, efficient, and environmentally-friendly process has been developed for the synthesis of L-proline triflate ionic liquid (L-ProTfO) from L-proline and triflic acid using ultrasound irradiation. The combination of Lproline triflate ionic liquid technology with microwave energy represents an attractive and rapid alternative to the conventional acid-base-catalyzed thermal process. The current method has several advantages, including high yield, short reaction time, and work-up simplicity. In addition, the L-proline triflate ionic liquid could be recycled and reused four times without a noticeable decrease in catalytic activity. [GRAPHICS] .

引用

页码：406 / 415

页数：10

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