The role of gut microbiota in the development of type 1, type 2 diabetes mellitus and obesity

被引：203

作者：

Tai, Ningwen ^{[1
]}

Wong, F. Susan ^{[2
]}

Wen, Li ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Internal Med, Endocrinol Sect, New Haven, CT 06510 USA

[2] Cardiff Univ, Inst Mol & Expt Med, Sch Med, Cardiff CF10 3AX, S Glam, Wales

来源：

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS | 2015年 / 16卷 / 01期

关键词：

Gut microbiota; Type; 1; diabetes; 2; Obesity; GLUTEN-FREE DIET; INTESTINAL MICROBIOTA; INSULIN-RESISTANCE; HIGH-FAT; METABOLICALLY HEALTHY; INNATE IMMUNITY; CELIAC-DISEASE; CHILDREN; INFLAMMATION; BACTERIA;

D O I：

10.1007/s11154-015-9309-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetes is a group of metabolic disorders characterized by persistent hyperglycemia and has become a major public health concern. Autoimmune type 1 diabetes (T1D) and insulin resistant type 2 diabetes (T2D) are the two main types. A combination of genetic and environmental factors contributes to the development of these diseases. Gut microbiota have emerged recently as an essential player in the development of T1D, T2D and obesity. Altered gut microbiota have been strongly linked to disease in both rodent models and humans. Both classic 16S rRNA sequencing and shot-gun metagenomic pyrosequencing analysis have been successfully applied to explore the gut microbiota composition and functionality. This review focuses on the association between gut microbiota and diabetes and discusses the potential mechanisms by which gut microbiota regulate disease development in T1D, T2D and obesity.

引用

页码：55 / 65

页数：11

共 100 条

[1] Clinical and metabolic effects of gluten free diet in children with type 1 diabetes and coeliac disease [J].

Abid, Noina ;

McGlone, Oonagh ;

Cardwell, Chris ;

McCallion, William ;

Carson, Dennis .

PEDIATRIC DIABETES, 2011, 12 (04) :322-325

[2] A gluten-free diet lowers NKG2D and ligand expression in BALB/c and non-obese diabetic (NOD) mice [J].

Adlercreutz, E. H. ;

Weile, C. ;

Larsen, J. ;

Engkilde, K. ;

Agardh, D. ;

Buschard, K. ;

Antvorskov, J. C. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2014, 177 (02) :391-403

[3] Induction of Diabetes in the RIP-B7.1 Mouse Model Is Critically Dependent on TLR3 and MyD88 Pathways and Is Associated With Alterations in the Intestinal Microbiome [J].

Alkanani, Aimon K. ;

Hara, Naoko ;

Lien, Egil ;

Ir, Diana ;

Kotter, Cassandra V. ;

Robertson, Charles E. ;

Wagner, Brandie D. ;

Frank, Daniel N. ;

Zipris, Danny .

DIABETES, 2014, 63 (02) :619-631

[4]

[Anonymous], INT J OBES LOND

[5] Dietary gluten and the development of type 1 diabetes [J].

Antvorskov, Julie C. ;

Josefsen, Knud ;

Engkilde, Kayenre ;

Funda, David P. ;

Buschard, Karsten .

DIABETOLOGIA, 2014, 57 (09) :1770-1780

[6] Monitoring Bacterial Community of Human Gut Microbiota Reveals an Increase in Lactobacillus in Obese Patients and Methanogens in Anorexic Patients [J].

Armougom, Fabrice ;

Henry, Mireille ;

Vialettes, Bernard ;

Raccah, Denis ;

Raoult, Didier .

PLOS ONE, 2009, 4 (09)

[7]

Azad MB, 2014, INT J OBES LOND

[8] Why is the developed world obese? [J].

Bleich, Sara ;

Cutler, David ;

Murray, Christopher ;

Adams, Alyce .

ANNUAL REVIEW OF PUBLIC HEALTH, 2008, 29 :273-295

[9] The lean patient with type 2 diabetes: characteristics and therapy challenge [J].

Brunetti, P. .

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2007, 61 :3-9

[10] Differences in body composition between metabolically healthy obese and metabolically abnormal obese adults [J].

Camhi, S. M. ;

Katzmarzyk, P. T. .

INTERNATIONAL JOURNAL OF OBESITY, 2014, 38 (08) :1142-1145

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