Molecular docking and in vitro analysis of phyto-extracts from B. serrata for antibacterial activities

被引：10
|
作者：
Vakayil, Ramsi [1 ]
Anbazhagan, Murugesan [2 ]
Shanmugam, Gnanendra [3 ]
Ramasamy, Srinivasan [4 ]
Maghimaa, Mathanmohun [1 ]
机构：
[1] Muthayammal Coll Arts & Sci, Dept Microbiol, Namakkal, Tamil Nadu, India
[2] Govt Arts & Sci Coll, Dept Bot, Thiruvannamalai 606603, Tamil Nadu, India
[3] Origene Biosolut, Bioinformat Div, Salem 16, Tamil Nadu, India
[4] Tamil Nadu State Council Sci & Technol, Chennai, Tamil Nadu, India
来源：
BIOINFORMATION | 2021年 / 17卷 / 07期
关键词：
Plant extract; GCMS; bioactive compounds; Molecular docking; DOUBLE-BLIND; OSTEOARTHRITIS;
D O I：
10.6026/97320630017667
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The bioactives of Boswellia serrata have a role in ulcer healing therapies. Eleven bioactive compounds were obtained by GC-MS among which Cholan-24-oic acid, 3,12-bis (acetyl oxy) has a high molecular weight of 490.6719 with a retention time of 26.729. Twenty wound samples were collected aseptically from the labs and hospitals in and around the Namakkal districts of Tamilnadu, India. The antibacterial potential of E.coli showed a maximum inhibition of 27 mm against Tetracycline at 30 mu g. The ethanolic extract of the B. serrata shows a susceptibility of 19mm towards E. coli at 60 mu g concentration in MIC. Molecular docking results show the binding energy of Cholan-24-oic acid, 3,12-bis(acetyloxy)-8.6 (kcal/mol) followed by Pyrene, hexadecahydro-6.7(kcal/mol), and 5(1H)-Azulenone, 2,4,6,7,8,8a-hexahydro-3,8-dimethyl-4-(1-methylethylidene)-, (8S -cis)-6.4 (kcal/mol) for further consideration.
引用
收藏
页码：667 / 672
页数：6
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