Molecular docking and in vitro analysis of phyto-extracts from B. serrata for antibacterial activities

被引:10
作者
Vakayil, Ramsi [1 ]
Anbazhagan, Murugesan [2 ]
Shanmugam, Gnanendra [3 ]
Ramasamy, Srinivasan [4 ]
Maghimaa, Mathanmohun [1 ]
机构
[1] Muthayammal Coll Arts & Sci, Dept Microbiol, Namakkal, Tamil Nadu, India
[2] Govt Arts & Sci Coll, Dept Bot, Thiruvannamalai 606603, Tamil Nadu, India
[3] Origene Biosolut, Bioinformat Div, Salem 16, Tamil Nadu, India
[4] Tamil Nadu State Council Sci & Technol, Chennai, Tamil Nadu, India
关键词
Plant extract; GCMS; bioactive compounds; Molecular docking; DOUBLE-BLIND; OSTEOARTHRITIS;
D O I
10.6026/97320630017667
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The bioactives of Boswellia serrata have a role in ulcer healing therapies. Eleven bioactive compounds were obtained by GC-MS among which Cholan-24-oic acid, 3,12-bis (acetyl oxy) has a high molecular weight of 490.6719 with a retention time of 26.729. Twenty wound samples were collected aseptically from the labs and hospitals in and around the Namakkal districts of Tamilnadu, India. The antibacterial potential of E.coli showed a maximum inhibition of 27 mm against Tetracycline at 30 mu g. The ethanolic extract of the B. serrata shows a susceptibility of 19mm towards E. coli at 60 mu g concentration in MIC. Molecular docking results show the binding energy of Cholan-24-oic acid, 3,12-bis(acetyloxy)-8.6 (kcal/mol) followed by Pyrene, hexadecahydro-6.7(kcal/mol), and 5(1H)-Azulenone, 2,4,6,7,8,8a-hexahydro-3,8-dimethyl-4-(1-methylethylidene)-, (8S -cis)-6.4 (kcal/mol) for further consideration.
引用
收藏
页码:667 / 672
页数:6
相关论文
共 19 条
  • [1] Systemic effects of IL-17 in inflammatory arthritis
    Beringer, Audrey
    Miossec, Pierre
    [J]. NATURE REVIEWS RHEUMATOLOGY, 2019, 15 (08) : 491 - 501
  • [2] In vitro evaluation of alpha-tocopherol loaded carboxymethylcellulose chitosan copolymers as wound dressing materials
    Bilgic, Melike Bayindir
    Lacin, Nelisa Turkoglu
    Berber, Hale
    Mansuroglu, Banu
    [J]. MATERIALS TECHNOLOGY, 2019, 34 (07) : 386 - 393
  • [3] RCSB Protein Data Bank: biological macromolecular structures enabling research and education in fundamental biology, biomedicine, biotechnology and energy
    Burley, Stephen K.
    Berman, Helen M.
    Bhikadiya, Charmi
    Bi, Chunxiao
    Chen, Li
    Di Costanzo, Luigi
    Christie, Cole
    Dalenberg, Ken
    Duarte, Jose M.
    Dutta, Shuchismita
    Feng, Zukang
    Ghosh, Sutapa
    Goodsell, David S.
    Green, Rachel K.
    Guranovic, Vladimir
    Guzenko, Dmytro
    Hudson, Brian P.
    Kalro, Tara
    Liang, Yuhe
    Lowe, Robert
    Namkoong, Harry
    Peisach, Ezra
    Periskova, Irina
    Prlic, Andreas
    Randle, Chris
    Rose, Alexander
    Rose, Peter
    Sala, Raul
    Sekharan, Monica
    Shao, Chenghua
    Tan, Lihua
    Tao, Yi-Ping
    Valasatava, Yana
    Voigt, Maria
    Westbrook, John
    Woo, Jesse
    Yang, Huanwang
    Young, Jasmine
    Zhuravleva, Marina
    Zardecki, Christine
    [J]. NUCLEIC ACIDS RESEARCH, 2019, 47 (D1) : D464 - D474
  • [4] Farahpour, 2019, MED PLANTS WOUND HEA
  • [5] Inhibition of tumor-microenvironment interaction and tumor invasion by small-molecule allosteric inhibitor of DDR2 extracellular domain
    Grither, Whitney R.
    Longmore, Gregory D.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (33) : E7786 - E7794
  • [6] Haque S D, 2019, Mymensingh Med J, V28, P490
  • [7] Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study
    Haroyan, Armine
    Mukuchyan, Vahan
    Mkrtchyan, Nana
    Minasyan, Naira
    Gasparyan, Srbuhi
    Sargsyan, Aida
    Narimanyan, Mikael
    Hovhannisyan, Areg
    [J]. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2018, 18
  • [8] Evaluation of the effect of Elaeagnus angustifolia alone and combined with Boswellia thurifera compared with ibuprofen in patients with knee osteoarthritis: a randomized double-blind controlled clinical trial
    Karimifar, Mansoor
    Soltani, Rasool
    Hajhashemi, Valiollah
    Sarrafchi, Sara
    [J]. CLINICAL RHEUMATOLOGY, 2017, 36 (08) : 1849 - 1853
  • [9] Solvent extraction of vanadium from a stone coal acidic leach solution using D2EHPA/TBP: Continuous testing
    Li, Xingbin
    Deng, Zhigan
    Wei, Chang
    Li, Cunxiong
    Li, Minting
    Fan, Gang
    Huang, Hui
    [J]. HYDROMETALLURGY, 2015, 154 : 40 - 46
  • [10] Preparation of self-regulating/anti-adhesive hydrogels and their ability to promote healing in burn wounds
    Liang, Min
    Chen, Zhongmin
    Wang, Fuping
    Liu, Lan
    Wei, Runan
    Zhang, Mei
    [J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2019, 107 (05) : 1471 - 1482