Synthesis of lactams via copper-catalyzed intramolecular vinylation of amides

被引：120

作者：

Hu, TS ^{[1
]}

Li, CZ ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 10期

关键词：

D O I：

10.1021/ol0505555

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Copper-catalyzed intramolecular vinylation of iodoenamides were investigated for the first time. With Cul as the catalyst and N,N-dimethylethylenediamine as the ligand, a number of iodoenamides underwent cyclization in dioxane leading to the formations of five- to seven-membered lactams in moderate to excellent yields.

引用

页码：2035 / 2038

页数：4

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