Mechanism of CNS regulation by irisin, a multifunctional protein

被引：13

作者：

Qi, Jing-yu ^{[1
]}

Yang, Liu-kun ^{[1
]}

Wang, Xin-shang ^{[1
]}

Wang, Min ^{[1
]}

Li, Xu-bo ^{[1
]}

Feng, Ban ^{[1
]}

Wu, Yu-mei

Liu, Shui-bing ^{[1
]}

Zhang, Kun ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Sch Pharm, Dept Pharmacol, Xian 710032, Peoples R China

来源：

BRAIN RESEARCH BULLETIN | 2022年 / 188卷

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

Irisin; FNDC5; Neuroprotection; Exercise; FATTY-ACID OXIDATION; NEURAL DIFFERENTIATION; PHYSICAL-EXERCISE; TELOMERE LENGTH; FNDC5; OVEREXPRESSION; DOPAMINERGIC-NEURONS; ALZHEIMERS-DISEASE; INSULIN-RESISTANCE; INDUCED AUTOPHAGY; HORMONE IRISIN;

D O I：

10.1016/j.brainresbull.2022.07.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Exercise not only builds up our body but also improves cognitive function. Skeletal muscle secretes myokine during exercise as a large reservoir of signaling molecules, which can be considered as a medium between ex-ercise and brain health. Irisin is a circulating myokine derived from the Fibronectin type III domain-containing protein 5 (FNDC5). Irisin regulates energy metabolism because it can stimulate the "Browning" of white adipose tissue. It has been reported that irisin can cross the blood-brain barrier and increase the expression of a brain -derived neurotrophic factor (BDNF) in the hippocampus, which improves learning and memory. In addition, the neuroprotective effect of irisin has been verified in various disease models. Therefore, this review summarizes how irisin plays a neuroprotective role, including its signal pathway and mechanism. In addition, we will briefly discuss the therapeutic potential of irisin for neurological diseases.

引用

页码：11 / 20

页数：10

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