Cellular and paracellular transplants for spinal cord injury: a review of the literature

被引：10
作者：
Mortazavi, Martin M. [1 ]
Verma, Ketan [1 ]
Tubbs, R. Shane [1 ]
Theodore, Nicholas [2 ]
机构：
[1] Childrens Hosp, Birmingham, AL 35233 USA
[2] Barrow Neurol Inst, Dept Neurosurg, Phoenix, AZ 85013 USA
来源：
CHILDS NERVOUS SYSTEM | 2011年 / 27卷 / 02期
关键词：
Spinal cord; Injury; Paralysis; Treatment; NEURAL STEM-CELLS; NERVE-FIBER REGENERATION; VENTRAL ROOT AVULSION; AXONAL REGENERATION; FUNCTIONAL RECOVERY; ENSHEATHING CELLS; DELAYED TRANSPLANTATION; PROGENITOR CELLS; HYALURONIC-ACID; MOTOR RECOVERY;
D O I：
10.1007/s00381-010-1312-x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Experimental approaches to limit the spinal cord injury and to promote neurite outgrowth and improved function from a spinal cord injury have exploded in recent decades. Due to the cavitation resulting after a spinal cord injury, newer important treatment strategies have consisted of implanting scaffolds with or without cellular transplants. There are various scaffolds, as well as various different cellular transplants including stem cells at different levels of differentiation, Schwann cells and peripheral nerve implants, that have been reviewed. Also, attention has been given to different re-implantation techniques in avulsion injuries. Using standard search engines, this literature is reviewed. Cellular and paracellular transplantation for application to spinal cord injury offers promising results for those patients with spinal cord pathology.
引用
收藏
页码：237 / 243
页数：7
相关论文
共 86 条
[1]  
AGUAYO AJ, 1981, J EXP BIOL, V95, P231
[2]   Transplantation of clonal neural precursor cells derived from adult human brain establishes functional peripheral myelin in the rat spinal cord [J].
Akiyama, Y ;
Honmou, O ;
Kato, T ;
Uede, T ;
Hashi, K ;
Kocsis, JD .
EXPERIMENTAL NEUROLOGY, 2001, 167 (01) :27-39
[3]   Mechanically engineered hydrogel scaffolds for axonal growth and angiogenesis after transplantation in spinal cord injury [J].
Bakshi, A ;
Fisher, O ;
Dagci, T ;
Himes, BT ;
Fischer, I ;
Lowman, A .
JOURNAL OF NEUROSURGERY-SPINE, 2004, 1 (03) :322-329
[4]   MONOCLONAL-ANTIBODY TO CHICK-EMBRYO HYALURONAN-BINDING PROTEIN - CHANGES IN DISTRIBUTION OF BINDING-PROTEIN DURING EARLY BRAIN-DEVELOPMENT [J].
BANERJEE, SD ;
TOOLE, BP .
DEVELOPMENTAL BIOLOGY, 1991, 146 (01) :186-197
[5]   Rescue and sprouting of motoneurons following ventral root avulsion and reimplantation combined with intraspinal adeno-associated viral vector-mediated expression of glial cell line-derived neurotrophic factor or brain-derived neurotrophic factor [J].
Blits, B ;
Carlstedt, TP ;
Ruitenberg, MJ ;
de Winter, F ;
Hermens, WTJMC ;
Dijkhuizen, PA ;
Claasens, JWC ;
Eggers, R ;
van der Sluis, R ;
Tenenbaum, L ;
Boer, GJ ;
Verhaagen, J .
EXPERIMENTAL NEUROLOGY, 2004, 189 (02) :303-316
[6]   Intercostal nerve implants transduced with an adenoviral vector encoding neurotrophin-3 promote regrowth of injured rat corticospinal tract fibers and improve hindlimb function [J].
Blits, P ;
Dijkhuizen, PA ;
Boer, GJ ;
Verhaagen, J .
EXPERIMENTAL NEUROLOGY, 2000, 164 (01) :25-37
[7]  
Borgens RB, 2002, J EXP BIOL, V205, P1
[8]   Hyaluronan-CD44 interaction stimulates Rac1 signaling and PKNγ kinase activation leading to cytoskeleton function and cell migration in astrocytes [J].
Bourguignon, Lilly Y. W. ;
Gilad, Eli ;
Peyrollier, Karine ;
Brightman, Amy ;
Swanson, Raymond A. .
JOURNAL OF NEUROCHEMISTRY, 2007, 101 (04) :1002-1017
[9]   Olfactory ensheathing cells genetically modified to secrete GDNF to promote spinal cord repair [J].
Cao, L ;
Liu, L ;
Chen, ZY ;
Wang, LM ;
Ye, JL ;
Qiu, HY ;
Lu, CL ;
He, C .
BRAIN, 2004, 127 :535-549
[10]   Pluripotent stem cells engrafted into the normal or lesioned adult rat spinal cord are restricted to a glial lineage [J].
Cao, QL ;
Zhang, YP ;
Howard, RM ;
Walters, WM ;
Tsoulfas, P ;
Whittemore, SR .
EXPERIMENTAL NEUROLOGY, 2001, 167 (01) :48-58
123456789