Association of serum adiponectin level with albuminuria in chronic kidney disease patients

被引:25
作者
Kim, Ha Yeon [1 ]
Bae, Eun Hui [1 ]
Ma, Seong Kwon [1 ]
Chae, Dong Wan [2 ]
Choi, Kyu Hun [3 ]
Kim, Yong-Soo [4 ]
Hwang, Young-Hwan [5 ]
Ahn, Curie [2 ]
Kim, Soo Wan [1 ]
机构
[1] Chonnam Natl Univ, Sch Med, Dept Internal Med, 42 Jebongro, Kwangju 501757, South Korea
[2] Seoul Natl Univ, Dept Internal Med, Seoul, South Korea
[3] Yonsei Univ, Dept Internal Med, Severance Hosp, Seoul 120749, South Korea
[4] Catholic Univ Korea, Seoul St Marys Hosp, Dept Internal Med, Seoul, South Korea
[5] Eulji Univ, Eulji Gen Hosp, Dept Internal Med, Seoul, South Korea
基金
新加坡国家研究基金会;
关键词
Serum adiponectin; Albuminuria; Chronic kidney disease; CARDIOVASCULAR EVENTS; INSULIN-RESISTANCE; EXCRETION; RECEPTORS; RISK;
D O I
10.1007/s10157-015-1173-4
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Adiponectin, a peptide hormone secreted from adipocytes, exerts anti-diabetic, anti-atherogenic, and anti-inflammatory properties. We aimed to determine the relationship between serum adiponectin levels and albuminuria, and evaluate determinant factors for serum adiponectin in patients with chronic kidney disease (CKD). In total, 1442 CKD patients were included and divided into three groups according to their albumin-to-creatinine ratios: patients with normoalbuminuria (N = 228), microalbuminuria (N = 444), and macroalbuminuria (N = 761). Serum adiponectin was specifically assayed with a commercially available enzyme-linked immunosorbent assay kit. Serum adiponectin was significantly higher in patients with macroalbuminuria than in those without macroalbuminuria (9.7 +/- A 6.0, 12.4 +/- A 9.0, and 14.9 +/- A 11.0 mu g/mL in patients with normoalbuminuria, microalbuminuria, and macroalbuminuria, respectively). Univariate linear regression analysis showed that the serum adiponectin concentrations were correlated with age, the albumin-to-creatinine ratio, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol, whereas they were negatively correlated with body mass index, the estimated glomerular filtration rate, and serum albumin and triglyceride levels. The stepwise regression multiple analysis showed that sex; the estimated glomerular filtration rate; body mass index; total cholesterol, high-density lipoprotein cholesterol, and triglyceride levels; and logarithm of the albumin-to-creatinine ratio were independently associated with the logarithm of serum adiponectin levels (r = 0.55, p < 0.001). Serum adiponectin concentrations are higher in patients with increasing albuminuria, and these levels are associated with renal insufficiency and lipid profiles.
引用
收藏
页码:443 / 449
页数:7
相关论文
共 34 条
[1]   Adiponectin stimulates phosphorylation of AMP-activated protein kinase α in renal glomeruli [J].
Cammisotto, Philippe G. ;
Bendayan, Moise .
JOURNAL OF MOLECULAR HISTOLOGY, 2008, 39 (06) :579-584
[2]   The role of adiponectin in renal physiology and development of albuminuria [J].
Christou, Georgios A. ;
Kiortsis, Dimitrios N. .
JOURNAL OF ENDOCRINOLOGY, 2014, 221 (02) :R49-R61
[3]   High density lipoprotein is positively correlated with the changes in circulating total adiponectin and high molecular weight adiponectin during dietary and fenofibrate treatment [J].
Christou, Georgios A. ;
Tellis, Constantinos C. ;
Elisaf, Moses S. ;
Tselepis, Alexandros D. ;
Kiortsis, Dimitrios N. .
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM, 2012, 11 (02) :178-188
[4]   The role of the novel adipocyte-derived hormone adiponectin in human disease [J].
Díez, JJ ;
Iglesias, P .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2003, 148 (03) :293-300
[5]   K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification - Foreword [J].
Eknoyan, G ;
Levin, NW .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2002, 39 (02) :S14-S266
[6]   Possible relationship between adiponectin and renal tubular injury in diabetic nephropathy [J].
Fujita, Hlroki ;
Morii, Tsukasa ;
Koshimura, Jun ;
Ishikawa, Motoko ;
Kato, Masako ;
Miura, Takeshi ;
Sasaki, Hiroshi ;
Narita, Takuma ;
Ito, Seiki ;
Kakei, Masafumi .
ENDOCRINE JOURNAL, 2006, 53 (06) :745-752
[7]   Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals [J].
Gerstein, HC ;
Mann, JFE ;
Yi, QL ;
Zinman, B ;
Dinneen, SF ;
Hoogwerf, B ;
Hallé, JP ;
Young, J ;
Rashkow, A ;
Joyce, C ;
Nawaz, S ;
Yusuf, S .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 286 (04) :421-426
[8]   Adiponectin, the missing link in insulin resistance and obesity [J].
Gil-Campos, M ;
Cañete, R ;
Gil, A .
CLINICAL NUTRITION, 2004, 23 (05) :963-974
[9]   Adiponectin retards the progression of diabetic nephropathy in db/db mice by counteracting angiotensin II [J].
Guo, Xiaohua ;
Zhou, Guangyu ;
Guo, Meizi ;
Cheung, Alfred K. ;
Huang, Yufeng ;
Beddhu, Srinivasan .
PHYSIOLOGICAL REPORTS, 2014, 2 (02)
[10]   Histamine 3 Receptor Activation Reduces the Expression of Neuronal Angiotensin II Type 1 Receptors in the Heart [J].
Hashikawa-Hobara, Narumi ;
Chan, Noel Yan-Ki ;
Levi, Roberto .
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2012, 340 (01) :185-191