Longitudinal assessment of bone loss from diagnostic computed tomography scans in gynecologic cancer patients treated with chemotherapy and radiation

被引：32
作者：
Hui, Susanta K. [1 ]
Khalil, Ali [2 ]
Zhang, Yan [6 ]
Coghill, Kathleen [1 ]
Le, Chap [3 ]
Dusenbery, Kathryn [1 ]
Froelich, Jerry [2 ]
Yee, Douglas [4 ]
Downs, Levi [5 ]
机构：
[1] Univ Minnesota, Dept Therapeut Radiol, Sch Med, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Dept Radiol, Sch Med, Minneapolis, MN 55455 USA
[3] Univ Minnesota, Dept Biostat, Sch Med, Minneapolis, MN 55455 USA
[4] Univ Minnesota, Dept Med, Sch Med, Minneapolis, MN 55455 USA
[5] Univ Minnesota, Dept Obstet & Gynecol, Sch Med, Minneapolis, MN 55455 USA
[6] Univ Minnesota, Biostat & Informat Core Mason Canc Ctr, Sch Med, Minneapolis, MN 55455 USA
来源：
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2010年 / 203卷 / 04期
关键词：
bone loss; chemotherapy; quantitative computed tomography; radiation; PELVIC FRACTURES; DENSITY; WOMEN; THERAPY;
D O I：
10.1016/j.ajog.2010.06.001
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
OBJECTIVE: The objective of the study was to measure the volumetric bone mineral density (vBMD) using diagnostic computed tomography scans in gynecologic oncology patients. STUDY DESIGN: In a retrospective study, spine and femoral neck (FN) vBMD was measured for 1 year in 40 patients receiving chemotherapy or radiation. RESULTS: There is significant bone loss after chemotherapy, radiation, and a combination of radiation and chemotherapy (P = .0211). In 1 year, the percent reduction in vBMD (+/-SE) at L1-L2 spine and the FN was a 15.9% (+/-5.67) and 10.4% (+/-4.06) in chemotherapy; 11% (+/-5.68) and 15.8% (+/-2.56) in radiation; and 21.0% (+/-7.03) and 3.6% (+/-3.3.7) in the combined therapy group. Bone loss was evident immediately after treatment and persisted or worsened in most women. CONCLUSION: Gynecologic cancer patients treated with chemotherapy or radiation experience immediate and prolonged bone loss; thus, pre- and posttreatment monitoring of bone loss is important in these patients.
引用
收藏
页码：353.e1 / 353.e7
页数：7
相关论文
共 11 条
  • [1] Adams JE, 2000, J BONE MINER RES, V15, pS169
  • [2] Risk of pelvic fractures in older women following pelvic irradiation
    Baxter, NN
    Habermann, EB
    Tepper, JE
    Durham, SB
    Virnig, BA
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2005, 294 (20): : 2587 - 2593
  • [3] BONE-DENSITY AT VARIOUS SITES FOR PREDICTION OF HIP-FRACTURES
    CUMMINGS, SR
    BLACK, DM
    NEVITT, MC
    BROWNER, W
    CAULEY, J
    ENSRUD, K
    GENANT, HK
    PALERMO, L
    SCOTT, J
    VOGT, TM
    [J]. LANCET, 1993, 341 (8837) : 72 - 75
  • [4] Predictors of bone mineral loss in patients with ovarian cancer treated with anticancer agents
    Douchi, T
    Kosha, S
    Kan, RH
    Nakamura, S
    Oki, T
    Nagata, Y
    [J]. OBSTETRICS AND GYNECOLOGY, 1997, 90 (01) : 12 - 15
  • [5] Genant HK, 2000, CLIN ORTHOP RELAT R, P3
  • [6] Radiation-therapy effects on bone density
    Hopewell, JW
    [J]. MEDICAL AND PEDIATRIC ONCOLOGY, 2003, 41 (03): : 208 - 211
  • [7] HUI SK, J CLIN DENS IN PRESS
  • [8] PREDICTING VERTEBRAL FRACTURE INCIDENCE FROM PREVALENT FRACTURES AND BONE-DENSITY AMONG NON-BLACK, OSTEOPOROTIC WOMEN
    ROSS, PD
    GENANT, HK
    DAVIS, JW
    MILLER, PD
    WASNICH, RD
    [J]. OSTEOPOROSIS INTERNATIONAL, 1993, 3 (03) : 120 - 126
  • [9] Pelvic fractures following radiation therapy for cervical cancer: Implications for survivors
    Schmeler, K. M.
    Jhingran, A.
    Iyer, R. B.
    Sun, C. C.
    Eifel, P. J.
    Soliman, P. T.
    Ramirez, P. T.
    Frumovitz, M.
    Bodurka, D. C.
    Sood, K.
    [J]. GYNECOLOGIC ONCOLOGY, 2008, 111 (02) : 382 - 382
  • [10] VEHMANEN L, EFFECTS CHEMOTHERAPY
12